Reactome | CEP250 [cytosol]

CEP250 [cytosol]

Stable Identifier

R-HSA-380263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep250/C-Nap1

Locations in the PathwayBrowser for interactor UniProt:P0DTD1-PRO_0000449630 REP

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Centrosome maturation (Homo sapiens)
        
        Loss of proteins required for interphase microtubule organization from the centrosome (Homo sapiens)
        
        Loss of C-Nap-1 from centrosomes (Homo sapiens)
        
        CEP250 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BV73 CEP250

Gene Names

CEP250, CEP2, CNAP1

Chain

chain:1-2442

Reference Genes

BioGPS Gene:11190 CEP250

COSMIC (genes):CEP250 CEP250

CTD Gene:11190 CEP250

dbSNP Gene:11190 CEP250

ENSEMBL:ENSG00000126001 CEP250

HGNC:1859 CEP250

KEGG:hsa:11190 CEP250

Monarch:11190 CEP250

NCBI Gene:11190 CEP250

OMIM:609689 CEP250

UCSC:Q9BV73 CEP250

Reference Transcript

Other Identifiers

11190

11722739_a_at

11752316_a_at

11753016_a_at

16913095

209495_PM_at

209495_at

210894_PM_s_at

210894_s_at

236424_PM_at

236424_at

2679190

35206_at

3883311

3883312

3883313

3883314

3883315

3883316

3883317

3883318

3883319

3883320

3883321

3883322

3883325

3883326

3883327

3883328

3883329

3883330

3883331

3883332

3883333

3883334

3883336

3883337

3883338

3883339

3883340

3883341

3883342

3883343

3883344

3883345

3883346

3883348

3883349

3883350

3883351

3883353

3883354

3883355

3883356

3883357

3883358

3883359

3883360

3883362

3883363

3883364

3883366

3883367

3883368

3883369

3883370

3883371

3883372

3883373

3883374

3883375

3883376

3883377

3883378

3883379

3883381

56138_at

56139_at

74643_at

8062137

A_23_P102832

A_24_P162287

GE54422

GE84948

GO:0000278

GO:0001750

GO:0001917

GO:0005515

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0008104

GO:0010457

GO:0019904

GO:0030030

GO:0030997

GO:0032991

GO:0033365

GO:0036064

GO:0043226

GO:0044782

GO:0048471

GO:0050908

GO:0060271

GO:0070062

GO:0071539

GO:1904781

GO:1905515

HMNXSV003008488

HMNXSV003030224

Hs.131488.0.A1_3p_at

ILMN_1799011

ILMN_2392940

PH_hs_0025798

TC20000253.hg

TC20000254.hg

g12655156_3p_s_at

g2832236_3p_at

p10570

Participates

as a component of

as an output of

Loss of C-Nap-1 from centrosomes (Homo sapiens)

Inferred To

CEP250 [cytosol] (Bos taurus)

CEP250 [cytosol] (Canis familiaris)

CEP250 [cytosol] (Gallus gallus)

CEP250 [cytosol] (Sus scrofa)

Ghost homologue of CEP250 [cytosol] (Xenopus tropicalis)

Cep250 [cytosol] (Mus musculus)

Cep250 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_006723754.1, XP_006723755.1, NP_001305148.1, XP_005260319.1, NP_009117.2, XP_006723753.1, XP_006723756.1

ENSEMBL

ENST00000397527, ENSP00000380661

OpenTargets

ENSG00000126001

HPA

ENSG00000126001-CEP250

PRO

Q9BV73

Pharos - Targets

Q9BV73

GlyGen

Q9BV73

PDB

6OQA

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H0K1 SIK2			0.619	5
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P0DTD1-PRO_0000449631 REP			0.556	3
UniProt:P0DTD1-PRO_0000449630 REP			0.527	2
UniProt:O88566	4	phospho-Axin2 [cytosol] (R-MMU-3640859) phospho-Axin2 [cytosol] (R-MMU-3640842) Axin2 [cytosol] (R-MMU-4641131) Axin2 [cytosol] (R-MMU-3640821)	0.463	3