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Centrosome maturation
Stable Identifier
R-HSA-380287
DOI
10.3180/REACT_15479.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Centrosome maturation (Homo sapiens)
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The centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an early event in this process and involves a major reorganization of centrosomal material at the G2/M transition. During maturation, centrosomes undergo a dramatic increase in size and microtubule nucleating capacity. As part of this process, a number of proteins and complexes, including some that are required for microtubule nucleation and anchoring, are recruited to the centrosome while others that are required for organization of interphase microtubules and centrosome cohesion are lost (reviewed in Schatten, 2008; Raynaud-Messina and Merdes 2007).
Literature References
PubMed ID
Title
Journal
Year
18437411
The mammalian centrosome and its functional significance
Schatten, H
Histochem Cell Biol
2008
17178454
Gamma-tubulin complexes and microtubule organization
Raynaud-Messina, B
,
Merdes, A
Curr Opin Cell Biol
2007
Participants
Events
Recruitment of mitotic centrosome proteins and complexes
(Homo sapiens)
Loss of proteins required for interphase microtubule organization from the centrosome
(Homo sapiens)
Participates
as an event of
G2/M Transition (Homo sapiens)
Orthologous Events
Centrosome maturation (Bos taurus)
Centrosome maturation (Canis familiaris)
Centrosome maturation (Gallus gallus)
Centrosome maturation (Mus musculus)
Centrosome maturation (Rattus norvegicus)
Centrosome maturation (Sus scrofa)
Centrosome maturation (Xenopus tropicalis)
Authored
Matthews, L (2008-11-11)
Reviewed
Merdes, A (2008-11-17)
Created
Matthews, L (2008-11-11)
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