Reactome | AZI1 [cytosol]

AZI1 [cytosol]

Stable Identifier

R-HSA-380295

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep131

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        AZI1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPN4 CEP131

Gene Names

CEP131, AZI1, KIAA1118

Chain

chain:1-1083

Reference Genes

BioGPS Gene:22994 CEP131

COSMIC (genes):CEP131 CEP131

CTD Gene:22994 CEP131

dbSNP Gene:22994 CEP131

ENSEMBL:ENSG00000141577 CEP131

HGNC:29511 CEP131

KEGG:hsa:22994 CEP131

Monarch:22994 CEP131

NCBI Gene:22994 CEP131

OMIM:613479 CEP131

UCSC:Q9UPN4 CEP131

Reference Transcript

Other Identifiers

11740624_a_at

16849746

214742_PM_at

214742_at

22994

32887_at

3773661

3773662

3773663

3773664

3773665

3773666

3773668

3773669

3773670

3773673

3773674

3773675

3773676

3773677

3773678

3773679

3773680

3773681

3773682

3773683

3773684

3773685

3773686

3773687

3773688

3773689

3773690

3773691

3773692

3773693

3773694

3773695

3773696

3773697

3773698

3773699

3773700

3773701

8019108

A_23_P319270

A_24_P66522

GE542069

GO:0001669

GO:0002177

GO:0005515

GO:0005654

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0006886

GO:0007010

GO:0007018

GO:0007283

GO:0007286

GO:0007288

GO:0008284

GO:0010824

GO:0022414

GO:0030030

GO:0030154

GO:0031410

GO:0031965

GO:0034451

GO:0035735

GO:0035869

GO:0036064

GO:0042073

GO:0042803

GO:0042995

GO:0043226

GO:0044782

GO:0044877

GO:0048856

GO:0060271

GO:0071539

GO:0090316

GO:0120212

GO:1905198

GO:1905515

GO:1990953

HMNXSV003054859

Hs.209646.0.S1_3p_at

ILMN_1742262

ILMN_1746206

PH_hs_0040533

TC17001945.hg

Participates

as a component of

Inferred To

CEP131 [cytosol] (Bos taurus)

CEP131 [cytosol] (Canis familiaris)

CEP131 [cytosol] (Sus scrofa)

AZI1 [cytosol] (Gallus gallus)

Ghost homologue of AZI1 [cytosol] (Xenopus tropicalis)

Cep131 [cytosol] (Mus musculus)

Cep131 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_055799.2, NP_001009811.2, NP_001306157.1

ENSEMBL

ENSP00000393583, ENST00000269392, ENSP00000269392, ENST00000374782, ENSP00000363914, ENST00000450824

OpenTargets

ENSG00000141577

HPA

ENSG00000141577-CEP131

PRO

Q9UPN4

Pharos - Targets

Q9UPN4

GlyGen

Q9UPN4

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.615	4

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