Reactome | CETN2 [cytosol]

CETN2 [cytosol]

Stable Identifier

R-HSA-380298

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Centrin-2

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CETN2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P41208 CETN2

Gene Names

CETN2, CALT, CEN2

Chain

initiator methionine:, chain:2-172

Reference Genes

BioGPS Gene:1069 CETN2

COSMIC (genes):CETN2 CETN2

CTD Gene:1069 CETN2

dbSNP Gene:1069 CETN2

ENSEMBL:ENSG00000147400 CETN2

ENSEMBL_homo_sapiens_GENE:ENSG00000147400.10 CETN2

ENSEMBL_homo_sapiens_GENE:ENSG00000292191.1 CETN2

HGNC:1867 CETN2

KEGG Gene (Homo sapiens):1069 CETN2

Monarch:1069 CETN2

NCBI Gene:1069 CETN2

OMIM:300006 CETN2

UCSC:P41208 CETN2

Reference Transcript

RefSeq:NM_004344.1 CETN2

Other Identifiers

1069

11731436_at

17115077

209194_PM_at

209194_at

38410_at

4026260

4026262

4026264

4026265

4026266

4026267

4026268

4026270

4026273

8175755

A_23_P73493

GE81384

GO:0000278

GO:0000910

GO:0005509

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0006281

GO:0006289

GO:0006974

GO:0007010

GO:0007049

GO:0007099

GO:0007283

GO:0008017

GO:0008092

GO:0015031

GO:0022414

GO:0031683

GO:0032391

GO:0032465

GO:0032795

GO:0036064

GO:0043226

GO:0044615

GO:0045177

GO:0046872

GO:0051028

GO:0051301

GO:0070390

GO:0071942

GO:0097729

HMNXSV003030971

ILMN_1695645

PH_hs_0004737

PH_hs_0035479

TC0X001506.hg

X72964_at

g13529121_3p_at

Participates

as a component of

Other forms of this molecule

CETN2 [nucleoplasm]

polySUMO2,3-CETN2 [nucleoplasm]

Inferred To

CETN2 [cytosol] (Bos taurus)

CETN2 [cytosol] (Canis familiaris)

CETN2 [cytosol] (Mus musculus)

CETN2 [cytosol] (Sus scrofa)

Cetn2 [cytosol] (Rattus norvegicus)

cetn2 [cytosol] (Xenopus tropicalis)

CETN1 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_004335.1

OpenTargets

ENSG00000147400

HPA

ENSG00000147400-CETN2

GeneCards

P41208

Ensembl

ENSP00000359300, ENST00000370277, ENSG00000147400

PRO

P41208

Pharos - Targets

P41208

HMDB Protein

HMDBP07583

PDB

8EBS, 2OBH, 2A4J, 8J07, 1ZMZ, 8EBW, 2GGM, 2K2I, 1M39, 8EBT, 8EBX, 8EBV

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NA72 POC5			0.915	14
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.901	14
UniProt:A8K8P3 SFI1	1	SFI1 [cytosol] (R-HSA-380265)	0.737	5
UniProt:Q2NKQ1-4 SGSM1			0.718	6
UniProt:Q9H0E7 USP44	1	USP44 [nucleoplasm] (R-HSA-5696942)	0.688	3
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.671	6
UniProt:Q8NA72-3 POC5			0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	13
UniProt:O14874 BCKDK	5	BCKDK [mitochondrial matrix] (R-HSA-5693129) R224P BCKDK [mitochondrial matrix] (R-HSA-9912466) R174Gfs1* BCKDK [mitochondrial matrix] (R-HSA-9912469) L389P BCKDK [mitochondrial matrix] (R-HSA-9912461) R156* BCKDK [mitochondrial matrix] (R-HSA-9912465)	0.643	3
UniProt:O43303 CCP110	2	CCP110 [cytosol] (R-HSA-380261) PolyUb-CCP110 [cytosol] (R-HSA-6783044)	0.641	5
UniProt:Q16513 PKN2	2	p-T816-PKN2 [cytosol] (R-HSA-5623652) PKN2 [cytosol] (R-HSA-5623612)	0.604	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:Q8IW19 APLF			0.527	2
UniProt:Q5VW00 DC122			0.527	2
UniProt:Q9BQ69 MACD1			0.527	2
UniProt:Q70CQ1 USP49	1	USP49 [nucleoplasm] (R-HSA-5696973)	0.527	2
UniProt:Q96A08 H2BC1	9	HIST1H2BA [nucleoplasm] (R-HSA-181916) Ub-122-HIST1H2BA [nucleoplasm] (R-HSA-3364020) AcK22-HIST1H2BA [nucleoplasm] (R-HSA-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-HSA-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-HSA-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-HSA-4568624) HIST1H2BA [extracellular region] (R-HSA-977582) AcK-HIST1H2BA [nucleoplasm] (R-HSA-4549263) Ub-HIST1H2BA [nucleoplasm] (R-HSA-6782561)	0.527	3
UniProt:Q2NKQ1 SGSM1			0.527	4
UniProt:Q12798 CETN1	7	PolyUb-Misfolded CETN1 [late endosome lumen] (R-HSA-9659982) CETN1 [cilium] (R-HSA-9639700) Misfolded CETN1 [cilium] (R-HSA-9639714) Misfolded CETN1 [cytosol] (R-HSA-9640113) Ub-Misfolded CETN1 [cytosol] (R-HSA-9641110) PolyUb-Misfolded CETN1 [cytosol] (R-HSA-9641126) PolyUb-Misfolded CETN1 [lysosomal lumen] (R-HSA-9659990)	0.527	4
UniProt:Q6ZNE5 ATG14	3	ATG14 [phagophore assembly site membrane] (R-HSA-5682389) ATG14 [endoplasmic reticulum membrane] (R-HSA-5679263) ATG14 [cytosol] (R-HSA-5668893)	0.527	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	3