Reactome | YWHAG [cytosol]

YWHAG [cytosol]

Stable Identifier

R-HSA-380312

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

14-3-3 protein gamma, 14-3-3 gamma

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        SARS-CoV-1-host interactions (Homo sapiens)
        
        SARS-CoV-1 targets host intracellular signalling and regulatory pathways (Homo sapiens)
        
        SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        14-3-3 dimer:SUMO1-K62-p-S177-Ncap dimer [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 targets host intracellular signalling and regulatory pathways (Homo sapiens)
        
        SARS-CoV-2 N binds to 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        14-3-3 dimer:N [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - FOXO-mediated transcription (Homo sapiens)
      - Regulation of localization of FOXO transcription factors (Homo sapiens)
        
        14-3-3 proteins bind AKT-phosphorylated FOXO1 (Homo sapiens)
        
        YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol] (Homo sapiens)
        
        YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        DDIT4 binds 14-3-3 dimer (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        DDIT4:14-3-3 dimer [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        DDIT4:14-3-3 dimer [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of BAD and translocation to mitochondria (Homo sapiens)
        
        Activation of BAD by calcineurin (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        Sequestration of BAD protein by 14-3-3 (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
    - 14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)
      - 14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - p-S237-TBC1D1:14-3-3 [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
    - 14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)
      - 14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)
      - p-5S,T642-AS160:14-3-3:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
        
        Phospho AS160:14-3-3 [cytoplasmic vesicle membrane] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAG dimer [cytosol] (Homo sapiens)
        
        YWHAG [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61981 YWHAG

Gene Names

YWHAG

Chain

initiator methionine:1, chain:1-247, chain:2-247

Reference Genes

BioGPS Gene:7532 YWHAG

COSMIC (genes):YWHAG YWHAG

CTD Gene:7532 YWHAG

dbSNP Gene:7532 YWHAG

ENSEMBL:ENSG00000170027 YWHAG

ENSEMBL:ENSG00000170027.7 YWHAG

HGNC:12852 YWHAG

KEGG Gene (Homo sapiens):7532 YWHAG

Monarch:7532 YWHAG

NCBI Gene:7532 YWHAG

OMIM:605356 YWHAG

UCSC:P61981 YWHAG

Reference Transcript

RefSeq:NM_012479.3 YWHAG

Other Identifiers

11744340_s_at

11746826_a_at

11749397_a_at

17058905

222985_PM_at

222985_at

3057651

3057652

3057661

3057662

3057663

44862_at

63282_f_at

65826_at

67256_at

7532

8140398

A_23_P123022

A_24_P106681

GE53664

GO:0003723

GO:0005080

GO:0005159

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005925

GO:0006469

GO:0006605

GO:0006886

GO:0007165

GO:0008426

GO:0009966

GO:0016020

GO:0019904

GO:0023052

GO:0030154

GO:0030971

GO:0031982

GO:0032869

GO:0036211

GO:0042802

GO:0043226

GO:0045202

GO:0045664

GO:0048167

GO:0048856

GO:0070062

GO:0098772

GO:0098793

HMNXSV003004536

ILMN_1750145

ILMN_2228809

PH_hs_0002201

TC07001540.hg

g6016837_3p_at

Participates

as a component of

Inferred To

14-3-3zeta [cytosol] (Drosophila melanogaster)

Ywhag [cytosol] (Rattus norvegicus)

par-5 [cytosol] (Caenorhabditis elegans)

14-3-3 gamma [cytosol] (Mus musculus)

Ghost homologue of YWHAG [cytosol] (Xenopus tropicalis)

Homologues of YWHAG [cytosol] (Caenorhabditis elegans)

fttB [cytosol] (Dictyostelium discoideum)

YWHAG [cytosol] (Bos taurus)

YWHAG [cytosol] (Caenorhabditis elegans)

YWHAG [cytosol] (Canis familiaris)

YWHAG [cytosol] (Danio rerio)

YWHAG [cytosol] (Gallus gallus)

YWHAG [cytosol] (Sus scrofa)

ftt-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_036611.2

OpenTargets

ENSG00000170027

HPA

ENSG00000170027-YWHAG

GeneCards

P61981

ZINC - Substances

1433G_HUMAN

Ensembl

ENSP00000306330, ENSG00000170027, ENST00000307630

ZINC target

P61981

PRO

P61981

Pharos - Targets

P61981

Orphanet

25774

HMDB Protein

HMDBP09172

PDB

6BZD, 6Y4K, 2B05, 4E2E, 3UZD, 6FEL, 6Y6B, 6ZC9, 6BYJ, 4J6S, 6GKF, 5D3E, 7A6Y, 6S9K, 6ZBT, 4O46, 6BYL, 7A6R, 6A5S, 6GKG, 6SAD

Interactors (86)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.928	10
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.886	19
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.883	8
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.857	8
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [cytosol] (R-HSA-8867650)	0.823	6
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.821	26
UniProt:Q02241 KIF23	3	KIF23 [nucleoplasm] (R-HSA-156709) p-S911,S912-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [cytosol] (R-HSA-1015863)	0.813	5
UniProt:P46937 YAP1	7	p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.806	5
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.763	5
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.758	4
UniProt:P00519 ABL1	5	p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.744	4
UniProt:P49815 TSC2	4	p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) TSC2 [cytosol] (R-HSA-2980548) p-S1387-TSC2 [cytosol] (R-HSA-3132769)	0.724	5
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.688	3
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.688	3
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.688	3
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.688	3
UniProt:Q8IYB3 SRRM1	2	SRRM1 [nucleoplasm] (R-HSA-156781) SRRM1 [cytosol] (R-HSA-159255)	0.688	3
UniProt:Q9UDY2 TJP2	4	TJP2 [cytosol] (R-HSA-2064412) TJP2 [nucleoplasm] (R-HSA-2064410) TJP2 [plasma membrane] (R-HSA-351862) TJP2(?-?) [plasma membrane] (R-HSA-351897)	0.688	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.688	3
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.688	3
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.688	3
UniProt:Q13009 TIAM1	2	p-Y829-TIAM1 [cytosol] (R-HSA-3928461) TIAM1 [cytosol] (R-HSA-195013)	0.688	3
UniProt:Q92574 TSC1	2	TSC1 [plasma membrane] (R-HSA-165169) TSC1 [cytosol] (R-HSA-5672338)	0.688	3
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.688	3
UniProt:P40818 USP8	2	USP8 [cytosol] (R-HSA-917720) p-T945-USP8 [cytosol] (R-HSA-1358714)	0.688	3
UniProt:P49840 GSK3A	3	GSK3A [cytosol] (R-HSA-198326) p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.688	3
UniProt:Q9UBF8 PI4KB	2	PI4KB [cytosol] (R-HSA-1604615) PI4KB [Golgi membrane] (R-HSA-1806202)	0.688	3
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.659	4
UniProt:P30305 CDC25B	3	p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [cytosol] (R-HSA-157412) CDC25B [nucleoplasm] (R-HSA-69734)	0.643	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.643	4
UniProt:P30307 CDC25C	8	p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741) p-S198-CDC25C [cytosol] (R-HSA-8981697) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [nucleoplasm] (R-HSA-156668)	0.643	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.643	5
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.643	4
UniProt:Q9HC77 CENPJ	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.64	3
UniProt:O14757 CHEK1	3	CHEK1 [cytosol] (R-HSA-205285) CHEK1 [nucleoplasm] (R-HSA-113826) p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838)	0.602	7
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.597	12
UniProt:Q92538 GBF1	2	GBF1 [Golgi membrane] (R-HSA-199994) GBF1 [cytosol] (R-HSA-6807751)	0.589	2
UniProt:O95232 LUC7L3	1	LUC7L3 [nucleoplasm] (R-HSA-9770258)	0.589	2
UniProt:O00273 DFFA	6	DFFA [cytosol] (R-HSA-211221) DFFA(1-?) [nucleoplasm] (R-HSA-211228) DFFA(225-331) [nucleoplasm] (R-HSA-211188) DFFA(118-224) [nucleoplasm] (R-HSA-211205) DFFA(118-331) [nucleoplasm] (R-HSA-211199) DFFA(1-117) [nucleoplasm] (R-HSA-211185)	0.589	2
UniProt:Q14739 LBR	4	LBR [endosome membrane] (R-HSA-9715094) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [nuclear envelope] (R-HSA-194637)	0.589	2
UniProt:Q13427 PPIG	2	PPIG [cytosol] (R-HSA-9728768) PPIG [nucleoplasm] (R-HSA-9769592)	0.589	2
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.589	2
UniProt:Q9UKV3 ACIN1	4	ACIN1 [nucleoplasm] (R-HSA-9770238) ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520)	0.589	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.589	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.589	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.589	2
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.589	2
UniProt:P30291 WEE1	3	p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) WEE1 [nucleoplasm] (R-HSA-69253)	0.564	2
UniProt:Q14966 ZNF638	1	ZNF638 [nucleoplasm] (R-HSA-8939429)	0.564	2
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.564	2
UniProt:Q9BZ23 PANK2	1	PANK2(111-570) [mitochondrial intermembrane space] (R-HSA-196803)	0.564	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.564	2
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.564	2
UniProt:Q5T1R4 HIVEP3	1	HIVEP3 [cytosol] (R-HSA-9008029)	0.558	2
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.556	3
UniProt:P17936 IGFBP3	15	IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963) IGFBP3 [extracellular region] (R-HSA-381512) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(28-168) [extracellular region] (R-HSA-381489)	0.556	3
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:P26951 IL3RA	1	IL3RA [plasma membrane] (R-HSA-879938)	0.556	3
UniProt:Q86T03 PIP4P1	2	TMEM55B [late endosome membrane] (R-HSA-6810395) TMEM55B [nucleoplasm] (R-HSA-6810405)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:Q9Y6X2 PIAS3	1	PIAS3 [nucleoplasm] (R-HSA-2993764)	0.556	3
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.556	3
UniProt:Q14032 BAAT	2	BAAT [cytosol] (R-HSA-159392) BAAT [peroxisomal matrix] (R-HSA-193517)	0.556	3
UniProt:P07225 PROS1	8	11xCbxE-PROS1 [platelet alpha granule lumen] (R-HSA-349762) 11xCbxE-PROS1 [extracellular region] (R-HSA-202772) 11xCbxE-PROS1 [plasma membrane] (R-HSA-141004) PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159758) 11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159770) 11xCbxE-PROS1(25-676) [Golgi membrane] (R-HSA-159850) PROS1(25-41) [Golgi lumen] (R-HSA-159792) 11xCbxE-PROS1 [Golgi membrane] (R-HSA-159865)	0.556	3
UniProt:P56693 SOX10	1	SOX10 [nucleoplasm] (R-HSA-9613639)	0.556	3
UniProt:O43598 DNPH1	1	DNPH1 [cytosol] (R-HSA-8953358)	0.556	3
UniProt:P51580 TPMT	5	TPMT [cytosol] (R-HSA-158628) TPMT A154T [cytosol] (R-HSA-5603333) TPMT A80P [cytosol] (R-HSA-5603346) TPMT A167G [cytosol] (R-HSA-5603357) TPMT Y240C [cytosol] (R-HSA-5603343)	0.556	3
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.556	3
UniProt:P51884 LUM	12	LUM [extracellular region] (R-HSA-2466189) N-glycan LUM [Golgi lumen] (R-HSA-2046297) Gal-glycan LUM [Golgi lumen] (R-HSA-2046248) Keratan(1)-LUM [Golgi lumen] (R-HSA-2046316) Keratan(2)-LUM [Golgi lumen] (R-HSA-2046233) Keratan(3)-LUM [Golgi lumen] (R-HSA-2046198) Keratan(4)-LUM [Golgi lumen] (R-HSA-2046205) KS(1)-LUM [Golgi lumen] (R-HSA-2046161) KS(2)-LUM [Golgi lumen] (R-HSA-2046249) KS(2)-LUM [extracellular region] (R-HSA-2046202) KS(2)-LUM [lysosomal lumen] (R-HSA-2046283) LUM [lysosomal lumen] (R-HSA-2104998)	0.556	3
UniProt:O94844 RHOBTB1	1	RHOBTB1 [endosome membrane] (R-HSA-194899)	0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:Q9NX63 CHCHD3	3	CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583) CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910)	0.556	3
UniProt:Q96PU5 NEDD4L	2	NEDD4L [cytosol] (R-HSA-976003) NEDD4L [nucleoplasm] (R-HSA-2176420)	0.547	2
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [cytosol] (R-HSA-1629773) WWTR1 [nucleoplasm] (R-HSA-1629775)	0.547	2
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.527	2
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.527	2
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.527	2
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.527	2
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.499	2
UniProt:Q96ST8 CEP89	1	CEP89 [cytosol] (R-HSA-5620930)	0.483	3

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