Reactome | CEP192 [cytosol]

CEP192 [cytosol]

Stable Identifier

R-HSA-380319

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep192

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP192 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TEP8 CEP192

Gene Names

CEP192, KIAA1569, PP8407

Chain

chain:1-2537

Reference Genes

BioGPS Gene:55125 CEP192

COSMIC (genes):CEP192 CEP192

CTD Gene:55125 CEP192

dbSNP Gene:55125 CEP192

ENSEMBL:ENSG00000101639 CEP192

HGNC:25515 CEP192

KEGG:hsa:55125 CEP192

Monarch:55125 CEP192

NCBI Gene:55125 CEP192

OMIM:616426 CEP192

UCSC:Q8TEP8 CEP192

Reference Transcript

RefSeq:NM_032142.3 CEP192

Other Identifiers

11742422_a_at

16851134

218827_PM_s_at

218827_s_at

3779800

3779818

3779820

3779822

3779823

3779824

3779828

3779829

3779830

3779834

3779835

3779836

3779845

3779846

3779847

3779848

3779849

3779850

3779851

3779852

3779853

3779854

3779855

3779856

3779857

3779858

3779861

3779862

3779863

3779864

3779865

3779866

3779867

3779868

3779869

3779870

3779871

3779872

3779873

3779874

3779875

3779878

3779879

3779883

3779884

3779885

3779886

3779887

3779888

3779889

3779890

3779891

3779893

3779895

3779896

3779897

3779898

3779904

3779905

3779908

3779912

3779913

3779914

3779915

3779926

3779927

3779928

3779929

3779939

3779941

3779947

55125

56128_at

68674_at

8020267

A_14_P202294

A_23_P89710

A_32_P217870

GE55719

GO:0000242

GO:0005515

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0007010

GO:0007099

GO:0009617

GO:0019901

GO:0019902

GO:0043226

GO:0051298

GO:0071539

GO:0090222

GO:0090307

GO:0120098

GO:0120099

HMNXSV003027595

HMNXSV003052547

ILMN_1703754

ILMN_1795897

ILMN_1797642

PH_hs_0031474

TC18000070.hg

g8922371_3p_a_at

Participates

as a component of

Inferred To

Ghost homologue of CEP192 [cytosol] (Bos taurus)

Ghost homologue of CEP192 [cytosol] (Xenopus tropicalis)

Cep192 [cytosol] (Mus musculus)

Cep192 [cytosol] (Rattus norvegicus)

SEH1L [cytosol] (Canis familiaris)

CEP192 [cytosol] (Gallus gallus)

CEP192 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_115518.3

ENSEMBL

ENST00000506447, ENSP00000427550

OpenTargets

ENSG00000101639

HPA

ENSG00000101639-CEP192

PRO

Q8TEP8

Pharos - Targets

Q8TEP8

GlyGen

Q8TEP8

PDB

6FVI, 6W3J, 4N7Z, 7PTB, 8GUW

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.802	8
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.544	2
UniProt:Q9Y2G2 CARD8	1	CARD8 [cytosol] (R-HSA-6805447)	0.527	2

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