Reactome | CEP72 [cytosol]

CEP72 [cytosol]

Stable Identifier

R-HSA-380321

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep72

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP72 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P209 CEP72

Gene Names

CEP72, KIAA1519

Chain

chain:1-647

Reference Genes

BioGPS Gene:55722 CEP72

COSMIC (genes):CEP72 CEP72

CTD Gene:55722 CEP72

dbSNP Gene:55722 CEP72

ENSEMBL:ENSG00000112877 CEP72

HGNC:25547 CEP72

KEGG:hsa:55722 CEP72

Monarch:55722 CEP72

NCBI Gene:55722 CEP72

OMIM:616475 CEP72

UCSC:Q9P209 CEP72

Reference Transcript

Other Identifiers

11743875_at

11749987_a_at

16982612

219531_PM_at

219531_at

2798796

2798797

2798798

2798799

2798801

2798807

2798808

2798809

2798811

2798812

2798813

2798814

2798815

2798816

2798820

2798824

2798831

2798832

2798833

2798834

2798835

2798836

2798837

2798838

2798840

2798841

2798842

2798843

2798867

2798868

55722

57985_at

8104220

A_23_P302654

GE55785

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0007010

GO:0007051

GO:0007099

GO:0033566

GO:0034451

GO:0043226

GO:1904779

HMNXSV003031750

HMNXSV003043814

ILMN_1800611

PH_hs_0005616

TC05000009.hg

TC05002175.hg

g8922520_3p_at

Participates

as a component of

Inferred To

Ghost homologue of CEP72 [cytosol] (Gallus gallus)

Ghost homologue of CEP72 [cytosol] (Xenopus tropicalis)

Cep72 [cytosol] (Mus musculus)

Cep72 [cytosol] (Rattus norvegicus)

CEP72 [cytosol] (Bos taurus)

CEP72 [cytosol] (Canis familiaris)

CEP72 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_060610.2, XP_011512365.1

ENSEMBL

ENSG00000112877, ENST00000264935, ENSP00000264935

OpenTargets

ENSG00000112877

GeneCards

CEP72

HPA

ENSG00000112877-CEP72

PRO

Q9P209

Pharos - Targets

Q9P209

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.718	8
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	5
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583)	0.556	3
UniProt:Q7L590 MCM10	1	MCM10 [nucleoplasm] (R-HSA-68403)	0.553	2

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