Reactome | Translocation of NuMA to the centrosomes

Translocation of NuMA to the centrosomes

Stable Identifier

R-HSA-380508

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Translocation of NuMA to the centrosomes

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After the nuclear envelope breakdown, phosphorylated NuMA rapidly moves to the centrosomal region (Compton and Luo 1995, Hsu and Yeh 1996, Kotak et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
7769006	Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis Compton, DA, Luo, C	J Cell Sci	1995
23921553	NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function Busso, C, Kotak, S, Gönczy, P	EMBO J.	2013
8838651	Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis Hsu, HL, Yeh, NH	J Cell Sci	1996