Reactome | PRKAA1 [cytosol]

PRKAA1 [cytosol]

Stable Identifier

R-HSA-380935

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMPK alpha1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, AAPK1_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Activation of AMPK downstream of NMDARs (Homo sapiens)
        
        CAMKK2 phosphorylates AMPK (Homo sapiens)
        
        AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK alpha [cytosol] (Homo sapiens)
        
        PRKAA1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13131 PRKAA1

Gene Names

PRKAA1, AMPK1

Chain

chain:1-559

Reference Genes

BioGPS Gene:5562 PRKAA1

COSMIC (genes):PRKAA1 PRKAA1

CTD Gene:5562 PRKAA1

dbSNP Gene:5562 PRKAA1

ENSEMBL:ENSG00000132356 PRKAA1

ENSEMBL_homo_sapiens_GENE:ENSG00000132356.12 PRKAA1

HGNC:9376 PRKAA1

KEGG Gene (Homo sapiens):5562 PRKAA1

Monarch:5562 PRKAA1

NCBI Gene:5562 PRKAA1

OMIM:602739 PRKAA1

UCSC:Q13131 PRKAA1

Reference Transcript

Other Identifiers

11729314_a_at

11739209_a_at

11751517_a_at

16995685

209799_PM_at

209799_at

225984_PM_at

225984_at

225985_PM_at

225985_at

2854734

2854736

2854738

2854739

2854740

2854741

2854742

2854743

2854746

2854747

2854749

2854753

2854755

2854758

2854760

2854765

2854776

2854777

2854778

2854779

41015_at

48068_at

5562

8111796

A_23_P110725

A_33_P3257187

A_33_P3312212

GE53597

GE878012

GE895807

GO:0000166

GO:0000785

GO:0001666

GO:0003682

GO:0003824

GO:0004672

GO:0004674

GO:0004679

GO:0004691

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0005975

GO:0006006

GO:0006091

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006468

GO:0006629

GO:0006631

GO:0006633

GO:0006694

GO:0006695

GO:0006886

GO:0006914

GO:0007005

GO:0007010

GO:0007165

GO:0008092

GO:0008202

GO:0008203

GO:0008284

GO:0008610

GO:0009410

GO:0009411

GO:0009631

GO:0010332

GO:0010508

GO:0010628

GO:0010629

GO:0012501

GO:0014823

GO:0015721

GO:0016055

GO:0016126

GO:0016192

GO:0016301

GO:0016310

GO:0016324

GO:0016607

GO:0016740

GO:0019395

GO:0023052

GO:0030424

GO:0030425

GO:0031000

GO:0031331

GO:0031588

GO:0031669

GO:0032007

GO:0032991

GO:0033135

GO:0034599

GO:0035556

GO:0036211

GO:0038183

GO:0042149

GO:0042542

GO:0042593

GO:0042752

GO:0043025

GO:0043066

GO:0043226

GO:0043627

GO:0044877

GO:0045542

GO:0045821

GO:0045893

GO:0046318

GO:0046627

GO:0046872

GO:0047322

GO:0048156

GO:0048511

GO:0048643

GO:0048856

GO:0050321

GO:0050405

GO:0050896

GO:0050995

GO:0055086

GO:0055089

GO:0060627

GO:0061744

GO:0061762

GO:0062028

GO:0070050

GO:0070301

GO:0070507

GO:0071277

GO:0071333

GO:0071361

GO:0071380

GO:0071417

GO:0071456

GO:0071466

GO:0097009

GO:0106310

GO:0120188

GO:0140053

GO:0140096

GO:0140823

GO:1901135

GO:1903109

GO:1903829

GO:1903944

GO:1903955

GO:1904179

GO:1904262

GO:1904428

GO:1905691

GO:1990044

GO:2000758

HMNXSV003036598

Hs.107057.0.A1_3p_at

Hs.107057.0.A2_3p_at

ILMN_1783889

ILMN_2357577

PH_hs_0022119

TC05001298.hg

Y12856_at

g5410311_3p_at

Participates

as a member of

AMPK alpha [cytosol] (Homo sapiens)

Other forms of this molecule

p-T183-PRKAA1 [cytosol]

p-T183-PRKAA1 [nucleoplasm]

Inferred To

Homologues of PRKAA1 [cytosol] (Caenorhabditis elegans)

Homologues of PRKAA1 [cytosol] (Dictyostelium discoideum)

Homologues of PRKAA1 [cytosol] (Saccharomyces cerevisiae)

Homologues of PRKAA1 [cytosol] (Schizosaccharomyces pombe)

Prkaa1 [cytosol] (Rattus norvegicus)

PRKAA1 [cytosol] (Bos taurus)

PRKAA1 [cytosol] (Caenorhabditis elegans)

PRKAA1 [cytosol] (Danio rerio)

PRKAA1 [cytosol] (Dictyostelium discoideum)

PRKAA1 [cytosol] (Drosophila melanogaster)

PRKAA1 [cytosol] (Gallus gallus)

PRKAA1 [cytosol] (Mus musculus)

PRKAA1 [cytosol] (Saccharomyces cerevisiae)

PRKAA1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_996790.3, NP_006242.5

Guide to Pharmacology - Targets

1541

OpenTargets

ENSG00000132356

IntEnz

2.7.11.31, 2.7.11.26

GeneCards

Q13131

HPA

ENSG00000132356-PRKAA1

ZINC target

Q13131

Ensembl

ENSP00000346148, ENST00000354209, ENST00000397128, ENSG00000132356, ENSP00000380317

PRO

Q13131

Pharos - Targets

Q13131

HMDB Protein

HMDBP01899

PDB

4RER, 4REW, 5EZV, 7JHG, 6C9F, 7JIJ, 6C9H, 7JHH, 6C9J, 7M74, 4RED, 6C9G

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145)	0.669	3
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.643	3
UniProt:P46937 YAP1	8	p-Y407-YAP1 [cytosol] (R-HSA-9865208) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.564	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	3

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