Reactome | LKB1 forms a trimeric complex with STRAD and MO25

LKB1 forms a trimeric complex with STRAD and MO25

Stable Identifier

R-HSA-380942

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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LKB1 forms a trimeric complex with STRAD and MO25

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Upon complex formation with STRAD and MO25, LKB1 (also known as serine/threonine kinase 11, STK11) is mostly cytosolic. LKB1 attains 20x activity towards the substrates belonging to the subfamily of AMPK-like kinases (5'AMP-activated protein kinases).

Literature References

PubMed ID	Title	Journal	Year
12805220	Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD Baas, AF, Boudeau, J, Sapkota, GP, Smit, L, Medema, R, Morrice, NA, Alessi, DR, Clevers, HC	EMBO J	2003
14517248	MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm Boudeau, J, Baas, AF, Deak, M, Morrice, NA, Kieloch, A, Schutkowski, M, Prescott, AR, Clevers, HC, Alessi, DR	EMBO J	2003