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STK11 [cytosol]
Stable Identifier
R-HSA-380954
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
LKB1
Locations in the PathwayBrowser for interactor UniProt:Q96L34 MARK4
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)
STK11 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15831 STK11
Gene Names
STK11, LKB1, PJS
Chain
chain:1-430, propeptide:431-433
Reference Genes
BioGPS Gene:6794 STK11
COSMIC (genes):STK11 STK11
CTD Gene:6794 STK11
dbSNP Gene:6794 STK11
ENSEMBL:ENSG00000118046 STK11
ENSEMBL_homo_sapiens_GENE:ENSG00000118046.17 STK11
HGNC:11389 STK11
KEGG Gene (Homo sapiens):6794 STK11
Monarch:6794 STK11
NCBI Gene:6794 STK11
OMIM:602216 STK11
UCSC:Q15831 STK11
Reference Transcript
RefSeq:XM_005259618.3 STK11
RefSeq:NM_000455.4 STK11
Other Identifiers
11735699_x_at
16856463
204292_PM_x_at
204292_x_at
231017_PM_at
231017_at
3815579
3815580
3815581
3815582
3815588
3815589
3815591
3815593
3815595
3815596
3815597
3815598
3815600
3815602
3815603
3815604
3815605
41657_PM_at
41657_at
6794
8024204
86312_at
A_23_P16483
A_33_P3389148
GO:0000166
GO:0000287
GO:0001558
GO:0001894
GO:0001944
GO:0002039
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006468
GO:0006470
GO:0006914
GO:0006915
GO:0006974
GO:0007018
GO:0007049
GO:0007163
GO:0007165
GO:0007283
GO:0007409
GO:0008285
GO:0010212
GO:0010508
GO:0012501
GO:0014823
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018107
GO:0022414
GO:0023052
GO:0030010
GO:0030018
GO:0030111
GO:0030154
GO:0030275
GO:0030295
GO:0030308
GO:0030511
GO:0032147
GO:0032991
GO:0033762
GO:0033993
GO:0034504
GO:0036211
GO:0042593
GO:0043226
GO:0043276
GO:0043434
GO:0044877
GO:0045059
GO:0045722
GO:0046777
GO:0046872
GO:0048814
GO:0048856
GO:0050772
GO:0050852
GO:0051645
GO:0051726
GO:0051896
GO:0060767
GO:0060770
GO:0070062
GO:0070314
GO:0071493
GO:0072332
GO:0090090
GO:0097066
GO:0097484
GO:0098772
GO:0106310
GO:0120163
GO:0140096
GO:0140535
GO:1900182
GO:1901610
GO:1901796
GO:1902554
GO:1904262
HMNXSV003049229
HMNXSV003056543
Hs.155647.0.S1_3p_at
ILMN_1751871
PH_hs_0015564
TC19001930.hg
TC19002617.hg
g4507270_3p_s_at
Participates
as an input of
LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)
as a component of
LKB1:STRAD:MO25 [cytosol] (Homo sapiens)
Other forms of this molecule
STK11 [nucleoplasm]
Inferred To
STK11 [cytosol]
(Bos taurus)
STK11 [cytosol]
(Canis familiaris)
STK11 [cytosol]
(Gallus gallus)
STK11 [cytosol]
(Mus musculus)
STK11 [cytosol]
(Rattus norvegicus)
STK11 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_005259675.1
,
NP_000446.1
ZINC - World Drugs
STK11_HUMAN
Guide to Pharmacology - Targets
2212
OpenTargets
ENSG00000118046
ZINC - FDA approved
STK11_HUMAN
ZINC - Substances
STK11_HUMAN
ZINC target
Q15831
ZINC - Biogenic
STK11_HUMAN
PRO
Q15831
PDB
4ZDR
,
2WTK
,
5WXN
ZINC - Investigational
STK11_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000118046-STK11
GeneCards
Q15831
Ensembl
ENSP00000324856
,
ENST00000326873
,
ENST00000652231
,
ENSP00000498804
,
ENSG00000118046
Pharos - Targets
Q15831
Orphanet
15565
ZINC - Predictions - Purchasable
STK11_HUMAN
HMDB Protein
HMDBP01530
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7RTN6 STRADA
1
STRADA [cytosol]
(R-HSA-380960)
0.953
22
UniProt:Q9Y376 CAB39
4
CAB39 [secretory granule lumen]
(R-HSA-6801288)
CAB39 [extracellular region]
(R-HSA-6806462)
CAB39 [ficolin-1-rich granule lumen]
(R-HSA-6801287)
CAB39 [cytosol]
(R-HSA-380969)
0.941
22
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.899
10
UniProt:Q9C0K7 STRADB
1
STRADB [cytosol]
(R-HSA-380976)
0.89
13
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.848
6
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.784
8
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.744
6
UniProt:Q9UNS2 COPS3
2
COPS3 [cytosol]
(R-HSA-416973)
COPS3 [nucleoplasm]
(R-HSA-5697017)
0.725
4
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.683
5
UniProt:Q9BT78 COPS4
2
COPS4 [nucleoplasm]
(R-HSA-5697020)
COPS4 [cytosol]
(R-HSA-416965)
0.669
4
UniProt:P48426 PIP4K2A
2
PIP4K2A [nucleoplasm]
(R-HSA-6811484)
PIP4K2A [cytosol]
(R-HSA-1604641)
0.643
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.61
6
UniProt:Q7RTN6-1 STRADA
0.564
3
UniProt:P36952 SPB5
0.547
2
UniProt:Q96L34 MARK4
1
MARK4 [cytosol]
(R-HSA-5626653)
0.544
2
UniProt:Q9NNW5 WDR6
1
WDR6 [cytosol]
(R-HSA-9715165)
0.543
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.536
3
UniProt:Q58FG1 HS904
0.527
4
UniProt:Q58FG0 HS905
0.527
4
UniProt:Q58FF6 H90B4
0.527
3
UniProt:Q58FF7 H90B3
0.527
2
UniProt:Q15018 FAM175B
1
FAM175B [cytosol]
(R-HSA-5691428)
0.527
3
UniProt:P61201 COPS2
2
COPS2 [cytosol]
(R-HSA-416971)
COPS2 [nucleoplasm]
(R-HSA-5697012)
0.527
2
UniProt:O75164 KDM4A
2
K48PolyUb-KDM4A [nucleoplasm]
(R-HSA-5683049)
KDM4A [nucleoplasm]
(R-HSA-351646)
0.527
3
UniProt:Q99627 COPS8
2
COPS8 [cytosol]
(R-HSA-416962)
COPS8 [nucleoplasm]
(R-HSA-5697014)
0.527
2
UniProt:Q13098 GPS1
2
GPS1 [nucleoplasm]
(R-HSA-5697010)
GPS1 [cytosol]
(R-HSA-416972)
0.527
2
UniProt:Q9H9S4 CAB39L
1
CAB39L [cytosol]
(R-HSA-380977)
0.527
2
UniProt:P26440 IVD
16
C360R IVD [mitochondrial matrix]
(R-HSA-9914809)
R340Q IVD [mitochondrial matrix]
(R-HSA-9914810)
T239I IVD [mitochondrial matrix]
(R-HSA-9914795)
R414L IVD [mitochondrial matrix]
(R-HSA-9914796)
L45P IVD [mitochondrial matrix]
(R-HSA-9914800)
A314V IVD [mitochondrial matrix]
(R-HSA-9914801)
M332T IVD [mitochondrial matrix]
(R-HSA-9914802)
R395C IVD [mitochondrial matrix]
(R-HSA-9914803)
IVD [mitochondrial matrix]
(R-HSA-70729)
R398Q IVD [mitochondrial matrix]
(R-HSA-9914799)
I379T IVD [mitochondrial matrix]
(R-HSA-9914797)
Y403N IVD [mitochondrial matrix]
(R-HSA-9914808)
D72N IVD [mitochondrial matrix]
(R-HSA-9914807)
V374A IVD [mitochondrial matrix]
(R-HSA-9914806)
R53P IVD [mitochondrial matrix]
(R-HSA-9914805)
G123R IVD [mitochondrial matrix]
(R-HSA-9914804)
0.527
2
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.527
2
UniProt:Q7Z6I8 CE024
0.527
2
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.527
2
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1079-LATS1 [cytosol]
(R-HSA-2028551)
0.499
2
UniProt:P26927 MST1
3
MST1(19-483) [extracellular region]
(R-HSA-6800207)
MST1(484-711) [extracellular region]
(R-HSA-6800230)
pro-MST1 [extracellular region]
(R-HSA-6800227)
0.499
2
UniProt:Q8TEW0 PARD3
3
PARD3 [plasma membrane]
(R-HSA-419980)
PARD3 [cytosol]
(R-HSA-419993)
PARD3 [cell junction]
(R-HSA-2134481)
0.463
2
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