Reactome | ERN1 [endoplasmic reticulum membrane]

ERN1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-381076

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

IRE1

Locations in the PathwayBrowser for interactor UniProt:Q86TM6 SYVN1

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External Reference Information

External Reference

UniProt:O75460 ERN1

Gene Names

ERN1, IRE1

Chain

signal peptide:1-18, chain:19-977

Reference Genes

BioGPS Gene:2081 ERN1

COSMIC (genes):ERN1 ERN1

CTD Gene:2081 ERN1

dbSNP Gene:2081 ERN1

ENSEMBL:ENSG00000178607 ERN1

HGNC:3449 ERN1

KEGG:hsa:2081 ERN1

Monarch:2081 ERN1

NCBI Gene:2081 ERN1

OMIM:604033 ERN1

UCSC:O75460 ERN1

Reference Transcript

RefSeq:NM_001433.3 ERN1

Participates

as an output of

IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)

as a component of

as an input of

IRE1 binds IRE1 forming dimer (Homo sapiens)

Other forms of this molecule

p-S724-ERN1 [endoplasmic reticulum membrane]

Inferred To

ern2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Ire1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Ern1 [endoplasmic reticulum membrane] (Rattus norvegicus)

ERN1 [endoplasmic reticulum membrane] (Bos taurus)

ERN1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

ERN1 [endoplasmic reticulum membrane] (Canis familiaris)

ERN1 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

ERN1 [endoplasmic reticulum membrane] (Gallus gallus)

ERN1 [endoplasmic reticulum membrane] (Mus musculus)

ERN1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

ERN1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cross References

Guide to Pharmacology - Targets

2020

OpenTargets

ENSG00000178607

ENSEMBL

ENSP00000475519, ENSG00000178607, ENSP00000401445, ENST00000606895, ENST00000433197

ZINC - FDA approved

ERN1_HUMAN

ZINC - Substances

ERN1_HUMAN

ZINC - Biogenic

ERN1_HUMAN

ZINC target

O75460

PRO

O75460

GlyGen

O75460

PDB

6XDB, 2HZ6, 6W39, 6HV0, 4YZ9, 6W3A, 6W3K, 6SHC, 6HX1, 6XDD, 6URC, 4Z7H, 6W3C, 6W3B, 7BMK, 4YZD, 4Z7G, 3P23, 4U6R, 6XDF, 5HGI, 4YZC, 8UVL, 6W3E

ZINC - Investigational

ERN1_HUMAN

HPA

ENSG00000178607-ERN1

GeneCards

ERN1

Pharos - Targets

O75460

ZINC - Predictions - Purchasable

ERN1_HUMAN

HMDB Protein

HMDBP08718

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.628	3
UniProt:O75460 ERN1	2	ERN1 [endoplasmic reticulum membrane] (R-HSA-381076) p-S724-ERN1 [endoplasmic reticulum membrane] (R-HSA-381029)	0.609	2
UniProt:Q969M3 YIPF5			0.537	3
UniProt:Q96HA8 NTAQ1			0.527	3
UniProt:Q8WWF5 ZNRF4			0.527	2
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.524	2
UniProt:Q07813	2	Bax [cytosol] (R-MMU-139907) Bax [mitochondrial outer membrane] (R-MMU-139949)	0.524	2
UniProt:Q9H2K8 TAOK3	1	TAOK3 [cytosol] (R-HSA-5423594)	0.508	3

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