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Go!
ATF4 [cytosol]
Stable Identifier
R-HSA-381084
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating ER-stress associated genes (Homo sapiens)
NFE2L2 dependent ATF4 expression (Homo sapiens)
ATF4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18848 ATF4
Gene Names
ATF4, CREB2, TXREB
Chain
chain:1-351
Reference Genes
BioGPS Gene:468 ATF4
COSMIC (genes):ATF4 ATF4
CTD Gene:468 ATF4
dbSNP Gene:468 ATF4
ENSEMBL:ENSG00000128272 ATF4
ENSEMBL_homo_sapiens_GENE:ENSG00000128272.18 ATF4
HGNC:786 ATF4
KEGG Gene (Homo sapiens):468 ATF4
Monarch:468 ATF4
NCBI Gene:468 ATF4
OMIM:604064 ATF4
UCSC:P18848 ATF4
Reference Transcript
RefSeq:NM_001675.4 ATF4
RefSeq:XM_017028807.1 ATF4
RefSeq:NM_182810.2 ATF4
Other Identifiers
11757047_x_at
16930299
200779_PM_at
200779_at
3349635
3349636
3349639
3349641
3349642
3349644
3771453
3771455
3771457
3771459
3945913
3945915
3945916
3945917
3945918
3945919
3945920
3945921
3945922
3945923
3945924
3945925
3945926
3945927
3945928
3945930
3945931
3945932
3945933
3996611
3996613
3996627
4027513
4027529
4027531
41235_at
468
8073148
8180337
A_23_P120933
A_23_P120941
D90209_at
GE81054
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005975
GO:0006094
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006520
GO:0006874
GO:0007214
GO:0007623
GO:0008140
GO:0009636
GO:0010575
GO:0010628
GO:0012501
GO:0016020
GO:0016071
GO:0016607
GO:0019901
GO:0023052
GO:0030154
GO:0030182
GO:0030282
GO:0030968
GO:0031667
GO:0032057
GO:0032590
GO:0032922
GO:0032991
GO:0034198
GO:0034399
GO:0034599
GO:0034644
GO:0034976
GO:0035162
GO:0036499
GO:0042149
GO:0042789
GO:0042802
GO:0042981
GO:0043005
GO:0043065
GO:0043226
GO:0043267
GO:0043522
GO:0043525
GO:0043565
GO:0045667
GO:0045893
GO:0045943
GO:0045944
GO:0046982
GO:0048167
GO:0048511
GO:0048856
GO:0055065
GO:0061629
GO:0070059
GO:0070169
GO:0070309
GO:0070982
GO:0071456
GO:0090575
GO:0120163
GO:0140110
GO:0140296
GO:0140297
GO:0140467
GO:0140468
GO:1903377
GO:1905461
GO:1990037
GO:1990253
GO:1990589
GO:1990590
GO:1990617
GO:1990737
GO:1990837
GO:1990841
GO:2000120
HMNXSV003057995
ILMN_1672128
ILMN_1783394
ILMN_2358457
PH_hs_0027945
RNA95126|RNS_208_189
TC22000317.hg
g4502264_3p_at
Participates
as an output of
NFE2L2 dependent ATF4 expression (Homo sapiens)
Other forms of this molecule
ATF4 [nucleoplasm]
Cross References
RefSeq
NP_001666.2
,
NP_877962.1
,
XP_016884296.1
OpenTargets
ENSG00000128272
GeneCards
P18848
HPA
ENSG00000128272-ATF4
Ensembl
ENST00000674835
,
ENSP00000336790
,
ENST00000674568
,
ENST00000674920
,
ENST00000404241
,
ENSG00000128272
,
ENSP00000384587
,
ENSP00000379912
,
ENST00000337304
,
ENST00000676346
,
ENSP00000505360
,
ENSP00000502610
,
ENSP00000501863
,
ENST00000396680
,
ENST00000679776
,
ENSP00000502400
,
ENSP00000501783
PRO
P18848
Pharos - Targets
P18848
HMDB Protein
HMDBP08114
PDB
1CI6
Interactors (45)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.951
21
UniProt:Q96RU7 TRIB3
3
TRIB3 [plasma membrane]
(R-HSA-199447)
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [nucleoplasm]
(R-HSA-9635877)
0.9
16
UniProt:Q13515 BFSP2
0.886
11
UniProt:P53567 CEBPG
1
CEBPG [nucleoplasm]
(R-HSA-9644320)
0.879
16
UniProt:Q9BWC9 CC106
0.87
14
UniProt:O14777 NDC80
1
NDC80 [cytosol]
(R-HSA-375314)
0.83
8
UniProt:Q13227 GPS2
1
GPS2 [nucleoplasm]
(R-HSA-351642)
0.83
13
UniProt:O95751 LDOC1
0.8
10
UniProt:P18847 ATF3
1
ATF3 [nucleoplasm]
(R-HSA-535543)
0.799
9
UniProt:Q9NS37 ZHANG
0.779
7
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.727
8
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.718
6
UniProt:Q92805 GOLGA1
1
GOLGA1 [cytosol]
(R-HSA-6813882)
0.718
11
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.713
5
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.706
4
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.683
4
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.668
3
UniProt:Q08AF8 GOG8F
0.666
7
UniProt:P19387 POLR2C
1
POLR2C [nucleoplasm]
(R-HSA-63506)
0.633
6
UniProt:P18848 ATF4
2
ATF4 [cytosol]
(R-HSA-381084)
ATF4 [nucleoplasm]
(R-HSA-381016)
0.623
2
UniProt:Q16520 BATF
1
BATF [nucleoplasm]
(R-HSA-6789925)
0.623
3
UniProt:O75444 MAF
1
MAF [nucleoplasm]
(R-HSA-8984728)
0.623
3
UniProt:P49715 CEBPA
1
CEBPA [nucleoplasm]
(R-HSA-381289)
0.623
4
UniProt:P17275 JUNB
1
JUNB [nucleoplasm]
(R-HSA-2186795)
0.622
3
IntAct:EBI-21404505 APOE
0.602
3
UniProt:Q3MII6 TBC1D25
1
TBC1D25 [autophagosome]
(R-HSA-8854607)
0.589
2
UniProt:Q9Y371 SHLB1
0.556
3
UniProt:O75400-2 PRPF40A
0.556
3
UniProt:Q96NT1 NP1L5
0.556
3
UniProt:Q9Y592-2 CEP83
0.556
3
UniProt:B7Z3H4 B7Z3H4
0.556
3
UniProt:A0A0S2Z507 A0A0S2Z507
0.556
6
UniProt:A2RTX5 SYTC2
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:Q86UD0 SAPC2
0.556
3
UniProt:Q9BXS5 AP1M1
7
AP1M1 [cytoplasmic vesicle membrane]
(R-HSA-351196)
AP1M1 [Golgi membrane]
(R-HSA-350805)
AP1M1 [lysosomal membrane]
(R-HSA-432708)
AP1M1 [trans-Golgi network membrane]
(R-HSA-2130512)
AP1M1 [cytosol]
(R-HSA-167700)
AP1M1 [plasma membrane]
(R-HSA-6806311)
AP1M1 [specific granule membrane]
(R-HSA-6799365)
0.556
3
UniProt:Q0D2H9 GOG8D
0.556
3
UniProt:Q8WYK2 JDP2
0.556
3
UniProt:Q9NV70 EXOC1
2
EXOC1 [plasma membrane]
(R-HSA-2872284)
EXOC1 [cytosol]
(R-HSA-5623375)
0.556
3
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.556
3
UniProt:P33297
4
PSMC3 [cytosol]
(R-SCE-68774)
PSMC3 [ficolin-1-rich granule lumen]
(R-SCE-6800429)
PSMC3 [extracellular region]
(R-SCE-6806496)
PSMC3 [secretory granule lumen]
(R-SCE-6800917)
0.556
3
UniProt:Q9NRI5 DISC1
0.553
4
UniProt:Q99871 HAUS7
1
HAUS7 [cytosol]
(R-HSA-8855200)
0.553
3
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.553
2
UniProt:Q9Y297-2 BTRC
0.543
5
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