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Dimerization of PERK
Stable Identifier
R-HSA-381087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
Dimerization of PERK (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once dissociated from BiP, PERK (EIF2AK3) monomers form homodimers, the active form of the protein.
Literature References
PubMed ID
Title
Journal
Year
17956313
PERK in the life and death of the pancreatic beta-cell
Herbert, TP
Biochem Soc Trans
2007
11907036
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
Wek, RC
,
Vattem, KM
,
Ma, K
J Biol Chem
2002
Participants
Input
x 2
EIF2AK3 [endoplasmic reticulum membrane]
(Homo sapiens)
Output
PERK dimer [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
PERK regulates gene expression (Homo sapiens)
Orthologous Events
Dimerization of PERK (Bos taurus)
Dimerization of PERK (Caenorhabditis elegans)
Dimerization of PERK (Canis familiaris)
Dimerization of PERK (Drosophila melanogaster)
Dimerization of PERK (Gallus gallus)
Dimerization of PERK (Mus musculus)
Dimerization of PERK (Rattus norvegicus)
Dimerization of PERK (Sus scrofa)
Dimerization of PERK (Xenopus tropicalis)
Authored
May, B (2009-06-02)
Reviewed
Gillespie, ME (2008-12-02)
D'Eustachio, P (2008-12-02)
Matthews, L (2008-12-02)
Urano, F (2010-04-30)
Created
May, B (2008-11-19)
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