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XBP1-2 [nucleoplasm]
Stable Identifier
R-HSA-381096
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
XBP1(S), XBP1 isoform 2, XBP-1S
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)
Expression of XBP1(S) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
XBP1(S) activates chaperone genes (Homo sapiens)
Expression of ACADVL (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of ADD1 (Adducin alpha) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of ARFGAP1 (GAP) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of ATP6VOD1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of C19orf10 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of CTDSP2 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of CXXC1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of Cullin-7 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of DCTN1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of DDX11 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of DNAJB11 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of DNAJB9 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of DNAJC3 (p58IPK) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of EDEM (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of EXTL1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of EXTL2 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of EXTL3 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of FKBP14 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of GFPT1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of GOSR2 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of GSK3A (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of HDGF (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of HYOU1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of KDELR3 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of KLHDC3 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of LMNA (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of PDIA5 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of PDIA6 (Protein disulfide-isomerase A6) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of PLA2G4B (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of PPP2R5B (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of SERP1 (RAMP4) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of SHC1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of SRPR (SRP Receptor subunit alpha) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of SRPRB (SRP Receptor subunit beta) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of SSR1 (Trap alpha) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of SULT1A3 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of SYVN1 (HRD1) (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of Sec12 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of Sec31A (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of TATDN2 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of TPP1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of TSPYL2 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of Talin-1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of WFS1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of WIPI1 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of YIF1A (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
Expression of ZBTB17 (Homo sapiens)
XBP1-2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17861-2 XBP1
Gene Names
XBP1, TREB5, XBP2
Other Identifiers
11729575_a_at
16933535
3956588
3956590
3956591
3956592
3956593
3956594
3956597
3956598
3956600
3956604
3956607
3956608
39755_at
39756_g_at
71584_at
7494
8075182
A_23_P120845
A_24_P100228
GE60446
GE85922
GO:0000122
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001525
GO:0001558
GO:0001889
GO:0001934
GO:0001935
GO:0002020
GO:0002376
GO:0002639
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006511
GO:0006629
GO:0006633
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0006955
GO:0006986
GO:0006996
GO:0007155
GO:0007517
GO:0008284
GO:0010508
GO:0010832
GO:0012501
GO:0015031
GO:0016020
GO:0019901
GO:0023052
GO:0030154
GO:0030163
GO:0030331
GO:0030335
GO:0030512
GO:0030968
GO:0031062
GO:0031490
GO:0031625
GO:0031647
GO:0031648
GO:0031670
GO:0032008
GO:0032755
GO:0032869
GO:0034599
GO:0034976
GO:0035356
GO:0035470
GO:0035924
GO:0036211
GO:0036498
GO:0036500
GO:0036503
GO:0042060
GO:0042149
GO:0042307
GO:0042632
GO:0042802
GO:0043066
GO:0043226
GO:0043491
GO:0045348
GO:0045579
GO:0045582
GO:0045600
GO:0045766
GO:0045944
GO:0046982
GO:0048010
GO:0048666
GO:0048856
GO:0048870
GO:0051897
GO:0055089
GO:0055092
GO:0060612
GO:0070373
GO:0071073
GO:0071222
GO:0071230
GO:0071332
GO:0071333
GO:0071353
GO:0071375
GO:0071498
GO:0071499
GO:0090575
GO:0140110
GO:1900100
GO:1900102
GO:1900103
GO:1901985
GO:1902236
GO:1903489
GO:1904294
GO:1904707
GO:1904754
GO:1990418
GO:1990837
GO:2000347
GO:2000353
HMNXSV003054559
ILMN_1809433
ILMN_2365465
M31627_at
PH_hs_0028446
RNA147464|p0568_imsncRNA237
TC22000627.hg
g4827057_3p_s_at
Participates
as an output of
Expression of XBP1(S) (Homo sapiens)
XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus (Homo sapiens)
This entity regulates
Positively
Expression of ADD1 (Adducin alpha)
(Homo sapiens)
Expression of YIF1A
(Homo sapiens)
Expression of Talin-1
(Homo sapiens)
Expression of PDIA6 (Protein disulfide-isomerase A6)
(Homo sapiens)
Expression of CTDSP2
(Homo sapiens)
Expression of HYOU1
(Homo sapiens)
Expression of ARFGAP1 (GAP)
(Homo sapiens)
Expression of LMNA
(Homo sapiens)
Expression of EXTL2
(Homo sapiens)
Expression of PLA2G4B
(Homo sapiens)
Expression of SHC1
(Homo sapiens)
Expression of ACADVL
(Homo sapiens)
Expression of Sec31A
(Homo sapiens)
Expression of KDELR3
(Homo sapiens)
Expression of Cullin-7
(Homo sapiens)
Expression of PDIA5
(Homo sapiens)
Expression of ZBTB17
(Homo sapiens)
Expression of TSPYL2
(Homo sapiens)
Expression of ATP6VOD1
(Homo sapiens)
Expression of DNAJB9
(Homo sapiens)
Expression of SRPRB (SRP Receptor subunit beta)
(Homo sapiens)
Expression of FKBP14
(Homo sapiens)
Expression of KLHDC3
(Homo sapiens)
Expression of HDGF
(Homo sapiens)
Expression of GSK3A
(Homo sapiens)
Expression of DDX11
(Homo sapiens)
Expression of WFS1
(Homo sapiens)
Expression of SULT1A3
(Homo sapiens)
Expression of WIPI1
(Homo sapiens)
Expression of PPP2R5B
(Homo sapiens)
Expression of SERP1 (RAMP4)
(Homo sapiens)
Expression of C19orf10
(Homo sapiens)
Expression of SSR1 (Trap alpha)
(Homo sapiens)
Expression of EDEM
(Homo sapiens)
Expression of GOSR2
(Homo sapiens)
Expression of GFPT1
(Homo sapiens)
Expression of CXXC1
(Homo sapiens)
Expression of DNAJC3 (p58IPK)
(Homo sapiens)
Expression of DCTN1
(Homo sapiens)
Expression of TATDN2
(Homo sapiens)
Expression of EXTL1
(Homo sapiens)
Expression of Sec12
(Homo sapiens)
Expression of EXTL3
(Homo sapiens)
Expression of SYVN1 (HRD1)
(Homo sapiens)
Expression of DNAJB11
(Homo sapiens)
Expression of SRPR (SRP Receptor subunit alpha)
(Homo sapiens)
Expression of TPP1
(Homo sapiens)
Cross References
RefSeq
NP_005071.2
,
NP_001073007.1
OpenTargets
ENSG00000100219
GeneCards
P17861
HPA
ENSG00000100219-XBP1
Ensembl
ENST00000216037
,
ENSG00000100219
,
ENSP00000343155
,
ENSP00000216037
,
ENST00000344347
ZINC target
P17861
PRO
P17861
Pharos - Targets
P17861
PDB
6R7Q
,
6R6G
,
6R6P
,
6R5Q
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18850 ATF6
7
ATF6 [endoplasmic reticulum membrane]
(R-HSA-381222)
ATF6 [Golgi membrane]
(R-HSA-381000)
ATF6(1-419) [Golgi membrane]
(R-HSA-420815)
ATF6(1-380) [cytosol]
(R-HSA-381075)
ATF6(380-419) [Golgi membrane]
(R-HSA-420817)
ATF6(420-670) [Golgi membrane]
(R-HSA-420814)
ATF6(1-380) [nucleoplasm]
(R-HSA-381211)
0.623
4
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.591
3
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