Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MBTPS1 [Golgi membrane]
Stable Identifier
R-HSA-381108
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
S1P
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
ATF6B (ATF6-beta) activates chaperones (Homo sapiens)
MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
CREB3 factors activate genes (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3L1 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3L2 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3L3 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
MBTPS1 (S1P) cleaves CREB3L4 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
S1P hydrolyzes SREBP1A,1C,2 (Homo sapiens)
MBTPS1 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14703 MBTPS1
Gene Names
MBTPS1, KIAA0091, S1P, SKI1
Chain
signal peptide:1-17, propeptide:18-186, chain:187-1052
Reference Genes
BioGPS Gene:8720 MBTPS1
COSMIC (genes):MBTPS1 MBTPS1
CTD Gene:8720 MBTPS1
dbSNP Gene:8720 MBTPS1
ENSEMBL:ENSG00000140943 MBTPS1
ENSEMBL_homo_sapiens_GENE:ENSG00000140943.18 MBTPS1
HGNC:15456 MBTPS1
KEGG Gene (Homo sapiens):8720 MBTPS1
Monarch:8720 MBTPS1
NCBI Gene:8720 MBTPS1
OMIM:603355 MBTPS1
UCSC:Q14703 MBTPS1
Reference Transcript
RefSeq:NM_003791.3 MBTPS1
Other Identifiers
11715952_a_at
11715953_a_at
16828734
201620_PM_at
201620_at
217543_3p_s_at
217543_PM_s_at
217543_s_at
36964_at
3702294
3702295
3702296
3702297
3702304
3702308
3702311
3702314
3702316
3702320
3702322
3702323
3702324
3702325
3702326
3702327
3702328
3702333
3702337
3702339
3702340
3702341
3702342
3702343
3702345
3702346
3702347
3702348
3702351
8003089
8720
A_23_P14946
A_23_P14948
A_24_P378368
A_33_P3393941
D42053_at
GE57205
GO:0000139
GO:0000278
GO:0003824
GO:0004252
GO:0005515
GO:0005783
GO:0005788
GO:0005789
GO:0005794
GO:0005795
GO:0006508
GO:0006629
GO:0007040
GO:0007095
GO:0008202
GO:0008203
GO:0008233
GO:0008236
GO:0016020
GO:0016192
GO:0016485
GO:0016787
GO:0023052
GO:0030968
GO:0031293
GO:0034976
GO:0036500
GO:0043226
GO:0045540
GO:0051604
GO:0060627
GO:0140096
HMNXSV003028178
ILMN_1651719
ILMN_1767256
PH_hs_0004384
TC16001307.hg
TC16001988.hg
g4506774_3p_s_at
Other forms of this molecule
MBTPS1 [endoplasmic reticulum membrane]
p-MBTPS1 [endoplasmic reticulum lumen]
MBTPS1 [endoplasmic reticulum lumen]
Inferred To
Mbtps1 [Golgi membrane]
(Mus musculus)
Mbtps1 [Golgi membrane]
(Rattus norvegicus)
S1P [Golgi membrane]
(Drosophila melanogaster)
MBTPS1 [Golgi membrane]
(Bos taurus)
MBTPS1 [Golgi membrane]
(Canis familiaris)
MBTPS1 [Golgi membrane]
(Dictyostelium discoideum)
MBTPS1 [Golgi membrane]
(Gallus gallus)
MBTPS1 [Golgi membrane]
(Sus scrofa)
mbtps1 [Golgi membrane]
(Danio rerio)
mbtps1 [Golgi membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003782.1
Guide to Pharmacology - Targets
2381
OpenTargets
ENSG00000140943
ZINC - Substances
MBTP1_HUMAN
GeneCards
Q14703
HPA
ENSG00000140943-MBTPS1
Ensembl
ENSP00000344223
,
ENSG00000140943
,
ENST00000343411
ZINC target
Q14703
PRO
Q14703
Pharos - Targets
Q14703
ZINC - Predictions - Purchasable
MBTP1_HUMAN
HMDB Protein
HMDBP02784
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.643
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text