Reactome | CEBPA [nucleoplasm]

CEBPA [nucleoplasm]

Stable Identifier

R-HSA-381289

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CCAAT/enhancer-binding protein alpha, CEBPA_HUMAN

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Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
        
        CEBPA gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
        
        CEBPA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49715 CEBPA

Gene Names

CEBPA, CEBP

Chain

chain:1-358

Reference Genes

BioGPS Gene:1050 CEBPA

COSMIC (genes):CEBPA CEBPA

CTD Gene:1050 CEBPA

dbSNP Gene:1050 CEBPA

ENSEMBL:ENSG00000245848 CEBPA

HGNC:1833 CEBPA

Monarch:1050 CEBPA

NCBI Gene:1050 CEBPA

OMIM:116897 CEBPA

UCSC:P49715 CEBPA

Reference Transcript

Other Identifiers

1050

11726294_s_at

16871235

204039_PM_at

204039_at

32550_r_at

3858994

3858995

3858996

3858997

3858998

3858999

3859000

3859001

3859002

3859003

3859004

61119_at

8036004

A_23_P375494

A_24_P216165

A_24_P224727

GE60289

GO:0000050

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001228

GO:0001889

GO:0001892

GO:0002070

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005730

GO:0006091

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0007005

GO:0007219

GO:0008203

GO:0008283

GO:0008285

GO:0010628

GO:0019221

GO:0019900

GO:0030099

GO:0030154

GO:0030225

GO:0030324

GO:0030851

GO:0031490

GO:0032436

GO:0036488

GO:0042127

GO:0042593

GO:0042802

GO:0042803

GO:0043032

GO:0043226

GO:0043231

GO:0043565

GO:0045444

GO:0045600

GO:0045669

GO:0045786

GO:0045892

GO:0045893

GO:0045944

GO:0048839

GO:0048856

GO:0050729

GO:0050872

GO:0050873

GO:0051726

GO:0055088

GO:0061629

GO:0070102

GO:0071285

GO:0071356

GO:0071407

GO:0071425

GO:0071941

GO:0090575

GO:0097009

GO:0097677

GO:0140110

GO:0140297

GO:0140467

GO:1902034

GO:1990647

HMNXSV003010716

ILMN_1715715

PH_hs_0004394

TC19001396.hg

TC19002442.hg

U34070_s_at

Participates

as an output of

as an input of

as a component of

This entity regulates

Positively

Inferred To

CEBPA [nucleoplasm] (Gallus gallus)

CEBPA [nucleoplasm] (Sus scrofa)

Cebpa [nucleoplasm] (Mus musculus)

Cebpa [nucleoplasm] (Rattus norvegicus)

Mabi [nucleoplasm] (Drosophila melanogaster)

cebpa [nucleoplasm] (Danio rerio)

slbo [nucleoplasm] (Drosophila melanogaster)

Homologues of CEBPA [nucleoplasm] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000427514

OpenTargets

ENSG00000245848

HPA

ENSG00000245848-CEBPA

PRO

P49715

Pharos - Targets

P49715

Orphanet

CEBPA

PDB

8K8C, 6DC0

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.713	5
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.623	4
UniProt:P53567 CEBPG	1	CEBPG [nucleoplasm] (R-HSA-9644320)	0.623	4
UniProt:P49715 CEBPA	1	CEBPA [nucleoplasm] (R-HSA-381289)	0.623	2
UniProt:Q16520 BATF	1	BATF [nucleoplasm] (R-HSA-6789925)	0.623	3
UniProt:Q9Y2D1 ATF5	3	ATF5 [mitochondrial matrix] (R-HSA-9841250) ATF5 [cytosol] (R-HSA-9841253) ATF5 [nucleoplasm] (R-HSA-9653719)	0.623	2
UniProt:P06422 VE2			0.602	4
UniProt:P47902 CDX1			0.581	3
UniProt:P24001-2 IL32			0.576	7
UniProt:P03122 VE2			0.544	2
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.499	2

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