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RXRA [nucleoplasm]
Stable Identifier
R-HSA-381319
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Retinoic acid receptor RXR-alpha, RXRA_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q15596 NCOA2
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Formation of PPARG:RXRA heterodimer (ARF6 complex) (Homo sapiens)
RXRA [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
PPARG binds RXRA (Homo sapiens)
RXRA [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Recycling of bile acids and salts (Homo sapiens)
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)
RXRA [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA binds RXRA (Homo sapiens)
RXRA [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
SUMOylation of RXRA with SUMO1 (Homo sapiens)
RXRA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19793 RXRA
Gene Names
RXRA, NR2B1
Chain
chain:1-462
Reference Genes
BioGPS Gene:6256 RXRA
COSMIC (genes):RXRA RXRA
CTD Gene:6256 RXRA
dbSNP Gene:6256 RXRA
ENSEMBL:ENSG00000186350 RXRA
HGNC:10477 RXRA
KEGG:hsa:6256 RXRA
Monarch:6256 RXRA
NCBI Gene:6256 RXRA
OMIM:180245 RXRA
UCSC:P19793 RXRA
Reference Transcript
RefSeq:NM_002957.5 RXRA
RefSeq:NM_001291921.1 RXRA
Other Identifiers
11742843_a_at
11742844_a_at
17090917
17090936
202426_PM_s_at
202426_s_at
202449_PM_s_at
202449_s_at
3193367
3193368
3193370
3193371
3193372
3193382
3193383
3193384
3193389
3193390
3193391
3193392
3193393
3193396
3193399
3193400
3193408
3193410
3193412
3193413
3193414
3193415
3193416
3193418
32800_at
405_at
6256
8159127
A_14_P100547
A_14_P104460
A_23_P219176
A_23_P423197
A_24_P930985
GE568327
GE61154
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001221
GO:0001972
GO:0002157
GO:0003677
GO:0003690
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0008270
GO:0008289
GO:0009755
GO:0010875
GO:0016071
GO:0019899
GO:0030154
GO:0030501
GO:0032411
GO:0032526
GO:0035357
GO:0042277
GO:0042789
GO:0042802
GO:0042809
GO:0043226
GO:0043235
GO:0043401
GO:0043565
GO:0044323
GO:0045893
GO:0045944
GO:0046872
GO:0048384
GO:0050692
GO:0050693
GO:0060089
GO:0070564
GO:0070644
GO:0090575
GO:0140110
GO:1990837
HMNXSV003002266
HMNXSV003021752
Hs.20084.0.S1_3p_a_at
ILMN_1687315
PH_hs_0001748
TC09000782.hg
TC09000783.hg
X52773_at
g10862707_3p_a_at
Participates
as an input of
SUMOylation of RXRA with SUMO1 (Homo sapiens)
PPARG binds RXRA (Homo sapiens)
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)
Formation of PPARG:RXRA heterodimer (ARF6 complex) (Homo sapiens)
PPARA binds RXRA (Homo sapiens)
as a component of
NR1H2:RXRA [nucleoplasm] (Homo sapiens)
NR1H3:RXRA [nucleoplasm] (Homo sapiens)
PPARG2:RXRA Heterodimer [nucleoplasm] (Homo sapiens)
PPARG1:RXRA Heterodimer [nucleoplasm] (Homo sapiens)
p-Y78,Y102-PPARG2:RXRA Heterodimer [nucleoplasm] (Homo sapiens)
PPARG:RXRA Heterodimer [nucleoplasm] (Homo sapiens)
Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
RARA:RXRA [nucleoplasm] (Homo sapiens)
atRA:RARA:RXRA [nucleoplasm] (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
RXRA:PPARD [nucleoplasm] (Homo sapiens)
RARA,G:RXRA [nucleoplasm] (Homo sapiens)
RXRA:RARA,G:atRA [nucleoplasm] (Homo sapiens)
RARA,B:RXRA [nucleoplasm] (Homo sapiens)
RXRA:RARA,B:atRA [nucleoplasm] (Homo sapiens)
PPARA:RXRA heterodimer [nucleoplasm] (Homo sapiens)
Activated PPARA:RXRA [nucleoplasm] (Homo sapiens)
as a member of
NR [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K108-RXRA [nucleoplasm]
p-S21-RXRA [nucleoplasm]
RXRA [cytosol]
Inferred To
nhr-91 [nucleoplasm]
(Caenorhabditis elegans)
usp [nucleoplasm]
(Drosophila melanogaster)
RXRA [nucleoplasm]
(Bos taurus)
RXRA [nucleoplasm]
(Canis familiaris)
RXRA [nucleoplasm]
(Danio rerio)
RXRA [nucleoplasm]
(Gallus gallus)
RXRA [nucleoplasm]
(Mus musculus)
RXRA [nucleoplasm]
(Rattus norvegicus)
RXRA [nucleoplasm]
(Sus scrofa)
rxra [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002948.1
,
NP_001278850.1
ZINC - World Drugs
RXRA_HUMAN
Guide to Pharmacology - Targets
610
OpenTargets
ENSG00000186350
ENSEMBL
ENSP00000419692
,
ENST00000481739
ZINC - FDA approved
RXRA_HUMAN
ZINC - Substances
RXRA_HUMAN
ZINC - Biogenic
RXRA_HUMAN
ZINC target
P19793
PRO
P19793
GlyGen
P19793
PDB
6LB5
,
1MVC
,
7UW2
,
4PP5
,
2P1U
,
4RMC
,
4NQA
,
5MKU
,
3PCU
,
1MV9
,
5ZQU
,
4POJ
,
1FM6
,
3FAL
,
1FBY
,
1DSZ
,
5JI0
,
6FBQ
,
4POH
,
4K4J
,
1G1U
,
6A60
,
3E94
,
4RFW
,
8PP0
,
6JNR
,
1XLS
,
5MK4
,
7UW4
,
5UAN
,
1FM9
,
4N8R
,
2P1V
,
3OZJ
,
6FBR
,
2ZY0
,
7CFO
,
1G5Y
,
3R5M
,
4J5X
,
1XVP
,
4M8E
,
4ZSH
,
3DZU
,
3UVV
,
1RXR
,
5MKJ
,
3DZY
,
1BY4
,
1YNW
,
1K74
,
5EC9
,
6JNO
,
4ZO1
,
7NKE
,
3E00
,
6LB6
,
6XWG
,
5MJ5
,
4OC7
,
7B88
,
4RME
,
2NLL
,
3OAP
,
3KWY
,
4PP3
,
3H0A
,
5TBP
,
4CN3
,
6A5Z
,
4J5W
,
6A5Y
,
7BK4
,
3NSQ
,
5MMW
,
4CN7
,
2ZXZ
,
3R29
,
5LYQ
,
6STI
,
6LB4
,
1RDT
,
6SJM
,
6XWH
,
1XV9
,
2P1T
,
4RMD
,
6L6K
,
8HBM
,
4K6I
,
5Z12
,
3FUG
,
7A77
,
4N5G
,
1R0N
,
4CN5
,
1MZN
,
7B9O
,
4CN2
,
4M8H
,
3FC6
,
3R2A
,
6HN6
,
2ACL
,
3NSP
ZINC - Investigational
RXRA_HUMAN
ZINC - Metabolites
RXRA_HUMAN
HPA
ENSG00000186350-RXRA
Pharos - Targets
P19793
ZINC - Predictions - Purchasable
RXRA_HUMAN
HMDB Protein
HMDBP01926
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10276 RARA
3
RARA [nucleoplasm]
(R-HSA-446164)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
0.951
15
UniProt:Q15788 NCOA1
3
NCOA1 [nucleoplasm]
(R-HSA-442496)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
0.857
14
UniProt:P11473 VDR
2
VDR [nucleoplasm]
(R-HSA-375512)
polySUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
0.791
6
UniProt:Q15596 NCOA2
3
NCOA2 [nucleoplasm]
(R-HSA-376398)
NCOA2 (869-1464) [nucleoplasm]
(R-HSA-5603186)
monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm]
(R-HSA-4085305)
0.775
5
UniProt:P37231-1 PPARG
2
PPARG2 [nucleoplasm]
(R-HSA-9841931)
p-Y78,Y102-PPARG2 [nucleoplasm]
(R-HSA-9842025)
0.715
6
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.697
6
UniProt:P04625
3
polySUMO3-K283,K389-THRA-2 [nucleoplasm]
(R-GGA-4719416)
monoSUMO1-K283,K389-THRA-2 [nucleoplasm]
(R-GGA-4719442)
THRA [nucleoplasm]
(R-GGA-446180)
0.65
4
UniProt:P37231 PPARG
2
monoSUMO1-K107,K395-PPARG [nucleoplasm]
(R-HSA-4717444)
PPARG [nucleoplasm]
(R-HSA-446172)
0.64
3
UniProt:Q71SY5 MED25
1
MED25 [nucleoplasm]
(R-HSA-212414)
0.625
4
UniProt:Q13133 NR1H3
1
NR1H3 [nucleoplasm]
(R-HSA-8854957)
0.609
8
ChEBI:9352 SULINDAC
0.602
3
UniProt:P55055 NR1H2
3
NR1H2 [nucleoplasm]
(R-HSA-375500)
polySUMO2,3-K409,K447-NR1H2 [nucleoplasm]
(R-HSA-4720435)
NR1H2 [cytosol]
(R-HSA-9619753)
0.592
3
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.556
8
UniProt:O14503 BHLHE40
1
BHLHE40 [nucleoplasm]
(R-HSA-879741)
0.556
4
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.556
3
IntAct:EBI-15743714 COACTIVATOR PEPTIDE
0.544
2
UniProt:P97792-1 CXADR
0.544
2
UniProt:P48443 RXRG
1
RXRG [nucleoplasm]
(R-HSA-446170)
0.527
2
IntAct:EBI-11173918 IR1
0.524
2
UniProt:Q03463-PRO_0000278730
0.524
3
IntAct:EBI-11173879 P1
0.524
4
IntAct:EBI-11173957 P4
0.524
4
IntAct:EBI-11173936 P2
0.524
4
UniProt:P42224 STAT1
8
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.508
2
UniProt:Q9JLI4 NCOA6
0.508
2
IntAct:EBI-10055402 PXR-RE
0.499
3
IntAct:EBI-10055663 CP2C8
0.499
5
IntAct:EBI-10055654 CP2C8
0.499
5
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