Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS

Stable Identifier
Reaction [transition]
Homo sapiens
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Prostate specific Antigen (PSA, KLK3) cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 186 and 187. Other cleavage sites were observed but not reproducibly. These may have been caused by impurities in the PSA preparation.

Literature References
PubMed ID Title Journal Year
7525824 Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease

Cohen, P, Peehl, DM, Graves, HC, Rosenfeld, RG

J Endocrinol 1994
11751371 Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?

Hoeflich, A, Reisinger, R, Lahm, H, Kiess, W, Blum, WF, Kolb, HJ, Weber, MM, Wolf, E

Cancer Res 2001
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
8817670 Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth

Rajah, R, Katz, L, Nunn, S, Solberg, P, Beers, T, Cohen, P

Prog Growth Factor Res 1995
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
7525634 Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) fragments and IGFBP-5 proteolytic activity in human seminal plasma: a comparison of normal and vasectomized patients

Lee, KO, Oh, Y, Giudice, LC, Cohen, P, Peehl, DM, Rosenfeld, RG

J Clin Endocrinol Metab 1994
7538844 Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3

Fielder, PJ, Rosenfeld, RG, Graves, HC, Grandbois, K, Maack, CA, Sawamura, S, Ogawa, Y, Sommer, A, Cohen, P

Growth Regul 1994
1383255 Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma

Cohen, P, Graves, HC, Peehl, DM, Kamarei, M, Giudice, LC, Rosenfeld, RG

J Clin Endocrinol Metab 1992
10218588 The cleavage site specificity of human prostate specific antigen for insulin-like growth factor binding protein-3

Okabe, E, Kajihara, J, Usami, Y, Hirano, K

FEBS Lett 1999
Catalyst Activity

serine-type endopeptidase activity of Prostate Specific Antigen [extracellular region]

Orthologous Events
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