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IGFBP1 [extracellular region]
Stable Identifier
R-HSA-381513
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Insulin-like Growth Factor Binding Protein-1, IBP1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P05019 IGF1
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
Expression of IGFBP1 (Homo sapiens)
IGFBP1 [extracellular region] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
IGFBP1 [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)
IGFBP1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08833 IGFBP1
Gene Names
IGFBP1, IBP1
Chain
signal peptide:1-25, chain:26-259
Reference Genes
BioGPS Gene:3484 IGFBP1
COSMIC (genes):IGFBP1 IGFBP1
CTD Gene:3484 IGFBP1
dbSNP Gene:3484 IGFBP1
ENSEMBL:ENSG00000146678 IGFBP1
HGNC:5469 IGFBP1
KEGG:hsa:3484 IGFBP1
Monarch:3484 IGFBP1
NCBI Gene:3484 IGFBP1
OMIM:146730 IGFBP1
UCSC:P08833 IGFBP1
Reference Transcript
RefSeq:NM_000596.2 IGFBP1
Other Identifiers
11717473_s_at
1232_s_at
17045838
205302_PM_at
205302_at
3000516
3000517
3000518
3000519
3000521
3000522
3000524
3000526
3000527
3484
8132694
A_23_P42868
GE508365
GO:0005102
GO:0005515
GO:0005520
GO:0005576
GO:0005615
GO:0005788
GO:0005794
GO:0007165
GO:0008286
GO:0014070
GO:0019838
GO:0030307
GO:0031994
GO:0031995
GO:0032868
GO:0042246
GO:0043226
GO:0043567
GO:0048856
GO:0090090
HMNXSV003028591
ILMN_1728445
ILMN_2387385
M74587_rna1_s_at
PH_hs_0019089
TC07000294.hg
g4504614_3p_at
Participates
as an output of
Expression of IGFBP1 (Homo sapiens)
IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
as a component of
IGF:IGFBP1 [extracellular region] (Homo sapiens)
as an input of
IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)
Other forms of this molecule
p-IGFBP1 [endoplasmic reticulum lumen]
IGFBP1 [endoplasmic reticulum lumen]
Inferred To
IGFBP1 [extracellular region]
(Bos taurus)
IGFBP1 [extracellular region]
(Gallus gallus)
IGFBP1 [extracellular region]
(Sus scrofa)
Igfbp1 [extracellular region]
(Mus musculus)
Igfbp1 [extracellular region]
(Rattus norvegicus)
igfbp1a [extracellular region]
(Danio rerio)
igfbp1 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000587.1
ENSEMBL
ENSP00000275525
OpenTargets
ENSG00000146678
HPA
ENSG00000146678-IGFBP1
ZINC - Substances
IBP1_HUMAN
ZINC target
P08833
PRO
P08833
Pharos - Targets
P08833
PDB
2DSQ
,
1ZT5
,
1ZT3
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05019 IGF1
2
IGF1 [extracellular region]
(R-HSA-2404178)
IGF1 [platelet alpha granule lumen]
(R-HSA-139878)
0.623
2
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:O14901 KLF11
0.556
3
UniProt:Q9H7X3 ZNF696
1
ZNF696 [nucleoplasm]
(R-HSA-2454138)
0.527
2
UniProt:Q9BX10 GTPBP2
2
GTPBP2 [extracellular region]
(R-HSA-8863001)
GTPBP2 [platelet alpha granule lumen]
(R-HSA-8862960)
0.527
2
UniProt:Q6UX71 PXDC2
0.527
2
UniProt:P26045 PTPN3
3
PTPN3 [cytosol]
(R-HSA-8867650)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [plasma membrane]
(R-HSA-5490317)
0.527
2
UniProt:Q9UHI8 ADAMTS1
4
ADAMTS1 [extracellular region]
(R-HSA-3791292)
ADAMTS1 [endoplasmic reticulum lumen]
(R-HSA-5173121)
glc-fuc-ADAMTS1 [endoplasmic reticulum lumen]
(R-HSA-5173006)
O-fuc-ADAMTS1 [endoplasmic reticulum lumen]
(R-HSA-5172971)
0.527
2
UniProt:O60279 SUSD5
0.527
2
UniProt:Q15654 TRIP6
0.527
2
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
0.527
2
UniProt:P01033 TIMP1
4
TIMP1 [platelet alpha granule lumen]
(R-HSA-349745)
p-TIMP1 [endoplasmic reticulum lumen]
(R-HSA-8957082)
TIMP1 [endoplasmic reticulum lumen]
(R-HSA-8956691)
TIMP1 [extracellular region]
(R-HSA-349743)
0.527
2
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