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AKAP5 [plasma membrane]
Stable Identifier
R-HSA-381669
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
AKAP79
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
ROBO receptors bind AKAP5 (Homo sapiens)
AKAP5 recruits PKA to ROBO2 (Homo sapiens)
ROBO2:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
ROBO2:AKAP5:PRKAR2A-PKA type II [plasma membrane] (Homo sapiens)
ROBO2:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 recruits PKC to ROBO2 (Homo sapiens)
ROBO2:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
ROBO2:AKAP5:p-T497,T638,S657-PRKCA [plasma membrane] (Homo sapiens)
ROBO2:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 recruits PKC to ROBO3.1 (Homo sapiens)
ROBO3.1:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
ROBO3.1:AKAP5:p-T497,T638,S657-PRKCA [plasma membrane] (Homo sapiens)
ROBO3.1:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 recruits PPP3CB (PP2BB) to ROBO2 (Homo sapiens)
ROBO2:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
ROBO2:AKAP5:PPP3CB [plasma membrane] (Homo sapiens)
ROBO2:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
PKC phosphorylates ROBO3.1 (Homo sapiens)
ROBO3.1:AKAP5:p-T497,T638,S657-PRKCA [plasma membrane] (Homo sapiens)
ROBO3.1:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
p-S1330-ROBO3.1:AKAP5:p-T497,T638,S657-PRKCA [plasma membrane] (Homo sapiens)
p-S1330-ROBO3.1:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
ROBO2 binds AKAP5 (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
ROBO2:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
ROBO3.1 binds AKAP5 (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
ROBO3.1:AKAP5 [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)
PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
cAMP:PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
Trafficking of AMPA receptors (Homo sapiens)
Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
AKAP5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24588 AKAP5
Gene Names
AKAP5, AKAP79
Chain
chain:1-427
Reference Genes
BioGPS Gene:9495 AKAP5
COSMIC (genes):AKAP5 AKAP5
CTD Gene:9495 AKAP5
dbSNP Gene:9495 AKAP5
ENSEMBL:ENSG00000179841 AKAP5
ENSEMBL_homo_sapiens_GENE:ENSG00000179841.8 AKAP5
HGNC:375 AKAP5
KEGG Gene (Homo sapiens):9495 AKAP5
Monarch:9495 AKAP5
NCBI Gene:9495 AKAP5
OMIM:604688 AKAP5
UCSC:P24588 AKAP5
Reference Transcript
RefSeq:NM_004857.3 AKAP5
Other Identifiers
11729077_at
11745674_a_at
16785361
207800_PM_at
207800_at
230846_PM_at
230846_at
32421_at
3540069
3540070
3540071
3540072
3540073
3540075
3540077
3540078
3540080
3540082
3540084
50873_r_at
7975066
9495
A_14_P101726
A_23_P106103
GE81448
GO:0005515
GO:0005516
GO:0005768
GO:0005829
GO:0005886
GO:0006886
GO:0007165
GO:0007193
GO:0007194
GO:0007268
GO:0008179
GO:0008287
GO:0009898
GO:0010738
GO:0014069
GO:0016020
GO:0016192
GO:0017124
GO:0023052
GO:0030346
GO:0031410
GO:0031698
GO:0032590
GO:0034237
GO:0035254
GO:0043197
GO:0043226
GO:0045121
GO:0045202
GO:0045762
GO:0050811
GO:0051018
GO:0055085
GO:0060076
GO:0060090
GO:0070886
GO:0072659
GO:0097110
GO:0098837
GO:0098944
GO:1900273
GO:1903078
GO:1905665
GO:1905751
HMNXSV003051309
Hs.22902.0.A1_3p_at
ILMN_1690818
M90359_at
PH_hs_0003411
TC14000389.hg
TC14001730.hg
g4757739_3p_at
Participates
as a component of
cAMP:PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
ROBO2:AKAP5 [plasma membrane] (Homo sapiens)
p-S1330-ROBO3.1:AKAP5 [plasma membrane] (Homo sapiens)
ROBO3.1:AKAP5 [plasma membrane] (Homo sapiens)
as an input of
ROBO2 binds AKAP5 (Homo sapiens)
ROBO3.1 binds AKAP5 (Homo sapiens)
as an output of
Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
Other forms of this molecule
AKAP5 [cytosol]
Inferred To
AKAP5 [plasma membrane]
(Bos taurus)
AKAP5 [plasma membrane]
(Canis familiaris)
AKAP5 [plasma membrane]
(Sus scrofa)
Akap5 [plasma membrane]
(Mus musculus)
Akap5 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_004848.3
OpenTargets
ENSG00000179841
HPA
ENSG00000179841-AKAP5
GeneCards
P24588
Ensembl
ENST00000320636
,
ENSG00000179841
,
ENSP00000378207
,
ENST00000394718
,
ENSP00000315615
PRO
P24588
Pharos - Targets
P24588
HMDB Protein
HMDBP08108
PDB
5NIN
,
2H9R
,
3LL8
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13861 PRKAR2A
2
PRKAR2A [cytosol]
(R-HSA-57840)
PRKAR2A [ciliary base]
(R-HSA-5610412)
0.76
5
UniProt:P31323 PRKAR2B
2
PRKAR2B [ciliary base]
(R-HSA-5610414)
PRKAR2B [cytosol]
(R-HSA-57842)
0.742
5
UniProt:P22694 PRKACB
3
PRKACB [ciliary base]
(R-HSA-5610404)
PRKACB [cytosol]
(R-HSA-57846)
PRKACB [nucleoplasm]
(R-HSA-111937)
0.725
4
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.725
4
UniProt:Q08209-1 PPP3CA
0.648
6
UniProt:P63098 PPP3R1
2
PPP3R1 [nucleoplasm]
(R-HSA-2685631)
PPP3R1 [cytosol]
(R-HSA-51291)
0.591
4
UniProt:P10644 PRKAR1A
4
PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713476)
PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713471)
PRKAR1A [ciliary base]
(R-HSA-5610408)
PRKAR1A [cytosol]
(R-HSA-57836)
0.556
3
UniProt:Q08209-2 PPP3CA
0.556
3
UniProt:Q9HAT0 ROPN1
1
ROPN1 [cytosol]
(R-HSA-5667048)
0.556
3
UniProt:Q96C74 ROP1L
0.556
3
UniProt:P63252 KCNJ2
1
KCNJ2 [plasma membrane]
(R-HSA-975378)
0.536
2
UniProt:P22612 PRKACG
3
PRKACG [ciliary base]
(R-HSA-5610405)
PRKACG [cytosol]
(R-HSA-57848)
PRKACG [nucleoplasm]
(R-HSA-111938)
0.527
2
UniProt:P35561 Kcnj2
2
Kcnj2 [plasma membrane]
(R-MMU-9729868)
Kcnj2 [plasma membrane]
(R-MMU-975378)
0.524
2
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