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NCK1,NCK2 [cytosol]
Stable Identifier
R-HSA-381949
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Nephrin binds NCK (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
Nephrin mediated activation of N-WASP (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Activation of RAC1 (Homo sapiens)
Activation of RAC1 by SOS (Homo sapiens)
SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
NCK binds ROBO1:SLIT2 (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
Recruitment of PAK to NCK (Homo sapiens)
SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:NCK:PAK [plasma membrane] (Homo sapiens)
SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
Recruitment of SOS to plasma membrane (Homo sapiens)
SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
Nck binds to the active PDGF receptor (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
CDC42:GTP binds PAK2 (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
FYN autophosphorylates (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
FYN phosphorylates PAK2 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
PAK2 autophorylates (Homo sapiens)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
PAK2 binds NCK (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
p-6Y-VEGFR2 binds FYN (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
p-6Y-VEGFR2 binds NCK (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
p-Y420-FYN is phosphorylated on S21 (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
p38 MAPK activation by VEGFR (Homo sapiens)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
Participants
members
NCK1 [cytosol]
(Homo sapiens)
NCK2 [cytosol]
(Homo sapiens)
Participates
as an input of
NCK binds ROBO1:SLIT2 (Homo sapiens)
Nephrin binds NCK (Homo sapiens)
p-6Y-VEGFR2 binds NCK (Homo sapiens)
Nck binds to the active PDGF receptor (Homo sapiens)
as a component of
SLIT2:ROBO1:NCK [plasma membrane] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Homo sapiens)
Inferred To
NCK1 [cytosol]
(Gallus gallus)
NCK1,NCK2 [cytosol]
(Bos taurus)
NCK1,NCK2 [cytosol]
(Caenorhabditis elegans)
NCK1,NCK2 [cytosol]
(Canis familiaris)
NCK1,NCK2 [cytosol]
(Danio rerio)
NCK1,NCK2 [cytosol]
(Drosophila melanogaster)
NCK1,NCK2 [cytosol]
(Mus musculus)
NCK1,NCK2 [cytosol]
(Rattus norvegicus)
NCK1,NCK2 [cytosol]
(Sus scrofa)
NCK1,NCK2 [cytosol]
(Xenopus tropicalis)
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