p130Cas and C3G bind PDGFR bound Crk

Stable Identifier
R-HSA-382052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The presence of both SH2 and SH3 domains in Crk proteins is of crucial importance for their function as adaptor molecules. Crk forms complex with Cas, an SH3 domain-containing docking protein which has been shown to be phosphorylated after PDGF-stimulation of cells, and C3G, a nucleotide exchange protein which has been linked to the activation of JNK.
Literature References
PubMed ID Title Journal Year
9546424 Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins

Saito, Y, Saito, Y, Mori, S, Ekman, S, Hellman, U, Yokote, K, Heldin, CH, Rönnstrand, L

Oncogene 1998
9739761 Signal transduction via platelet-derived growth factor receptors

Ostman, A, Heldin, CH, Rönnstrand, L

Biochim Biophys Acta 1998
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!