p130Cas and C3G bind PDGFR bound Crk

Stable Identifier
R-HSA-382052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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p130Cas and C3G bind PDGFR bound Crk
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The presence of both SH2 and SH3 domains in Crk proteins is of crucial importance for their function as adaptor molecules. Crk forms complex with Cas, an SH3 domain-containing docking protein which has been shown to be phosphorylated after PDGF-stimulation of cells, and C3G, a nucleotide exchange protein which has been linked to the activation of JNK.
Literature References
PubMed ID Title Journal Year
9546424 Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins

Saito, Y, Saito, Y, Mori, S, Ekman, S, Hellman, U, Yokote, K, Heldin, CH, Rönnstrand, L

Oncogene 1998
9739761 Signal transduction via platelet-derived growth factor receptors

Ostman, A, Heldin, CH, Rönnstrand, L

Biochim Biophys Acta 1998
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Orthologous Events
p130Cas and C3G bind PDGFR bound Crk (Bos taurus)
p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)
p130Cas and C3G bind PDGFR bound Crk (Drosophila melanogaster)
p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)
p130Cas and C3G bind PDGFR bound Crk (Mus musculus)
p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)
p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)
p130Cas and C3G bind PDGFR bound Crk (Xenopus tropicalis)
Authored
Jassal, B  (2008-11-24)
Garapati, P V  (2008-11-24)
Reviewed
Heldin, CH  (2008-11-24)
Created
Garapati, P V  (2008-11-22)
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