Reactome | PDGF binds to extracellular matrix proteins

PDGF binds to extracellular matrix proteins

Stable Identifier

R-HSA-382054

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PDGF binds to extracellular matrix proteins

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The long splice version of the PDGF-A chain as well as the COOH-terminal part of the PDGF-B precursor contain C-terminal protein motifs that confer retention of the secreted factors. In both the PDGF A- and B-chains, exon 6 encodes a basic sequence that mediates interaction with components of the extracellular matrix. PDGF binds to various types of collagens, thrombospondin and osteopontin; however, the major component of the matrix involved in PDGF binding is likely to be haparan sulphate. The negatively charged sulfate groups on the disaccharide building blocks of heparan sulfate (HS) polysaccharide chains provide binding sites for positively charged amino acid sequence motifs.
The precursor of the B-chain may be retained in the matrix; after maturation when the COOH-terminal retention sequence has been cleaved off, the molecule may become more diffusible.

Literature References

PubMed ID	Title	Journal	Year
10508235	Mechanism of action and in vivo role of platelet-derived growth factor Westermark, B, Heldin, CH	Physiol Rev	1999
9334164	Interaction of platelet-derived growth factor with thrombospondin 1 Chesterman, CN, Jiménez, BM, Stathakis, P, Hogg, PJ, Hotchkiss, KA	Biochem J	1997
8900172	Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB) Somasundaram, R, Schuppan, D	J Biol Chem	1996
1311092	The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors Sage, EH, Lane, TF, Iruela-Arispe, ML, Ross, R, Raines, EW	Proc Natl Acad Sci U S A	1992