Reactome | Crk binds to the active PDGF receptor

Crk binds to the active PDGF receptor

Stable Identifier

R-HSA-382056

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Crk family of adaptor molecules consists of CrkI with one SH2 and one SH3 domains and CrkII and CrkL with one SH2 and two SH3 domains each. They bind to Tyr762 of the PDGF alpha-receptor and represent the only known SH2-domain containing molecule which binds with significantly higher affinity to the alpha-receptor than to the beta-receptor.

Literature References

PubMed ID	Title	Journal	Year
10508235	Mechanism of action and in vivo role of platelet-derived growth factor Westermark, B, Heldin, CH	Physiol Rev	1999
9546424	Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins Saito, Y, Saito, Y, Mori, S, Ekman, S, Hellman, U, Yokote, K, Heldin, CH, Rönnstrand, L	Oncogene	1998
9739761	Signal transduction via platelet-derived growth factor receptors Ostman, A, Heldin, CH, Rönnstrand, L	Biochim Biophys Acta	1998