Reactome | ABCA7:Apo1A-mediated phospholipid efflux

ABCA7:Apo1A-mediated phospholipid efflux

Stable Identifier

R-HSA-382553

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ABCA7:Apo1A-mediated phospholipid efflux

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids and may have a possible role in cellular phospholipid metabolism in peripheral tissues. Like many other ABC-transporters, the exact role of ABCA7 is waiting to be elucidated.

Literature References

PubMed ID	Title	Journal	Year
11095984	Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene Schmitz, G, Kaminski, WE, Piehler, A	Biochem Biophys Res Commun	2000
14570867	Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein Abe-Dohmae, S, Matsuo, M, Okuhira, K, Ikeda, Y, Hayashi, M, Yokoyama, S, Ueda, K	J Biol Chem	2004
12509503	Role of ABC transporters in secretion of cholesterol from liver into bile Small, DM	Proc Natl Acad Sci U S A	2003
14592415	Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release Amachi, T, Aoki, R, Munehira, Y, Furuya, A, Abe-Dohmae, S, Matsuo, M, Ikeda, Y, Yokoyama, S, Kioka, N, Shitara, K, Ueda, K, Kawamoto, S	Biochem Biophys Res Commun	2003
12917409	ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux Lan, D, Chen, W, Wang, N, Jehle, AW, Gerbod-Giannone, M, Tall, AR, Martinez, LO, Linsel-Nitschke, P	J Biol Chem	2003
10873640	Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7) Schmitz, G, Klucken, J, Orsó, E, Drobnik, W, Diederich, W, Kaminski, WE	Biochem Biophys Res Commun	2000