Reactome | HSPG2(22-4196) [extracellular region]

HSPG2(22-4196) [extracellular region]

Stable Identifier

R-HSA-3827968

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

HSPG2, Perlecan, Basement membrane-specific heparan sulfate proteoglycan core protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P98160 HSPG2

Gene Names

HSPG2

Chain

signal peptide:1-21, chain:22-4391, chain:3687-4391, chain:4197-4391

Reference Genes

BioGPS Gene:3339 HSPG2

COSMIC (genes):HSPG2 HSPG2

CTD Gene:3339 HSPG2

dbSNP Gene:3339 HSPG2

ENSEMBL:ENSG00000142798 HSPG2

HGNC:5273 HSPG2

KEGG:hsa:3339 HSPG2

Monarch:3339 HSPG2

NCBI Gene:3339 HSPG2

OMIM:142461 HSPG2

UCSC:P98160 HSPG2

Reference Transcript

Participates

as an output of

HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Homo sapiens)

Other forms of this molecule

HS(4)-HSPG2 [plasma membrane]

HS(6)-HSPG2 [plasma membrane]

HS(2)-HSPG2 [plasma membrane]

HS(1)-HSPG2 [plasma membrane]

HS(3)-HSPG2 [plasma membrane]

HS(5)-HSPG2 [plasma membrane]

HSPG2(3687-4391) [extracellular region]

HSPG2(22-4391) [Golgi lumen]

XylS-HSPG2(22-4391) [Golgi lumen]

Gal-Xyl-HSPG2 [Golgi lumen]

Gal-Gal-Xyl-HSPG2 [Golgi lumen]

GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen]

HS(2)-HSPG2 [Golgi lumen]

HS(3)-HSPG2 [Golgi lumen]

HS(1)-HSPG2 [Golgi lumen]

Heparan(4)-HSPG2 [Golgi lumen]

Heparan(3)-HSPG2 [Golgi lumen]

Heparan(2)-HSPG2 [Golgi lumen]

Heparan(1)-HSPG2 [Golgi lumen]

Heparan-HSPG2 [Golgi lumen]

HS(4)-HSPG2 [Golgi lumen]

HS(5)-HSPG2 [Golgi lumen]

HS(6)-HSPG2 [Golgi lumen]

HS(6)-HSPG2 [lysosomal lumen]

HSPG2(22-4391) [lysosomal lumen]

HSPG2(22-4391) [extracellular region]

Heparan sulfate-HSPG2 [extracellular region]

HSPG2(?-4391) [extracellular region]

HSPG2(22-?) [extracellular region]

HSPG2(4197-4391) [extracellular region]

Inferred To

DIP-epsilon [extracellular region] (Drosophila melanogaster)

DIP-kappa [extracellular region] (Drosophila melanogaster)

DIP-zeta [extracellular region] (Drosophila melanogaster)

DIP-alpha [extracellular region] (Drosophila melanogaster)

Homologues of HSPG2(22-4196) [extracellular region] (Caenorhabditis elegans)

Homologues of HSPG2(22-4196) [extracellular region] (Drosophila melanogaster)

Lac [extracellular region] (Drosophila melanogaster)

CT35363 [extracellular region] (Drosophila melanogaster)

rig-5 [extracellular region] (Caenorhabditis elegans)

DIP-eta [extracellular region] (Drosophila melanogaster)

fipi [extracellular region] (Drosophila melanogaster)

CT35293 [extracellular region] (Drosophila melanogaster)

HSPG2(22-4196) [extracellular region] (Caenorhabditis elegans)

DIP-delta [extracellular region] (Drosophila melanogaster)

DIP-gamma [extracellular region] (Drosophila melanogaster)

DIP-beta [extracellular region] (Drosophila melanogaster)

DIP-theta [extracellular region] (Drosophila melanogaster)

DIP-lambda [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_001278789.1, NP_005520.4

OpenTargets

ENSG00000142798

ENSEMBL

ENST00000374695, ENSP00000363827, ENSG00000142798

GeneCards

HSPG2

HPA

ENSG00000142798-HSPG2

PRO

P98160

Pharos - Targets

P98160

GlyGen

P98160

Orphanet

HSPG2

HMDB Protein

HMDBP01713

PDB

3SH5, 3SH4

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35968 KDR	5	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636)	0.719	5
UniProt:P05230 FGF1	1	FGF1 [extracellular region] (R-HSA-189856)	0.564	3
ChEBI:28304 HEPARIN			0.564	2
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.53	3
UniProt:Q9H9D4 ZN408			0.527	2