HCO3- transport through ion channel

Stable Identifier
R-HSA-383190
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Regulation of epithelial chloride flux, which is defective in patients with cystic fibrosis, may be mediated by phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cyclic AMP-dependent protein kinase (PKA) or protein kinase C (PKC). CFTR regulates both HCO(3)(-) secretion and HCO(3)(-) salvage in secretory epithelia.
Literature References
PubMed ID Title Journal Year
11562789 Na+:HCO(3-) cotransporters (NBC): cloning and characterization

Soleimani, M, Burnham, CE

J Membr Biol 2001
12403779 The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3

Choi, JY, Lee, MG, Ko, SB, Muallem, S, Pushkin, A, Thomas, PJ, Lee, MS, Muallem, G, Park, M, Kim, JY, Kurtz, I

J Biol Chem 2002
1377674 Phosphorylation of the cystic fibrosis transmembrane conductance regulator

Picciotto, MR, Bertuzzi, G, Greengard, P, Nairn, AC, Cohn, JA

J Biol Chem 1992
Participants
Participates
Catalyst Activity

chloride channel regulator activity of CFTR [plasma membrane]

Orthologous Events
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Reviewed
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