WNT-dependent phosphorylation of DVL

Stable Identifier
R-HSA-3858480
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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WNT-dependent phosphorylation of DVL
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In response to WNT signaling, dishevelled (DVL) proteins are phosphorylated within the C-terminus. This site appears to be common for both canonical and non-canonical WNT signaling as a similar phosphorylation pattern is observed upon stimulation with WNT1 and WNT5A and no discernable supershifted phosphoform is detected upon simultaneous treatment with both ligands (Gonzalez-Sancho et al, 2004). The kinase responsible for this phosphorylation has not been identified, although CK2, CK1 delta and epsilon and PAR1 have all been shown to phosphorylate DVL in vitro and in vivo under varying conditions (reviewed in Gao and Chen, 2010). WNT3a or WNT5a-induced phosphorylation sites are Ser594, Thr595 and Ser597 in Dvl2 (Gonzalez-Sancho et al. 2013).
Literature References
PubMed ID Title Journal Year
20006983 Dishevelled: The hub of Wnt signaling

Gao, C, Chen, YG

Cell. Signal. 2010
23396967 Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling

González-Sancho, JM, Greer, YE, Abrahams, CL, Takigawa, Y, Baljinnyam, B, Lee, KH, Lee, KS, Rubin, JS, Brown, AM

J. Biol. Chem. 2013
15143170 Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

González-Sancho, JM, Brennan, KR, Castelo-Soccio, LA, Brown, AM

Mol. Cell. Biol. 2004
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of unknown kinase [cytosol]

Physical Entity
unknown kinase [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Rat Dvl is phosophorylated upon Wnt binding (Mus musculus)
Authored
Rothfels, K  (2013-06-28)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-07-10)
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