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OXT(20-28) [extracellular region]
Stable Identifier
R-HSA-388430
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Oxytocin, RecName: Full=Oxytocin-neurophysin 1; Short=OT-NPI; Contains: RecName: Full=Oxytocin; AltName: Full=Ocytocin; Contains: RecName: Full=Neurophysin 1; Flags: Precursor;
GN Name=OXT; Synonyms=OT;
OS Homo sapiens, NEU1_HUMAN, OXT
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Vasopressin-like receptors (Homo sapiens)
Oxytocin receptor bind oxytocin (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01178 OXT
Gene Names
OXT, OT
Chain
signal peptide:1-19, peptide:20-28, chain:32-125
Reference Genes
BioGPS Gene:5020 OXT
COSMIC (genes):OXT OXT
CTD Gene:5020 OXT
dbSNP Gene:5020 OXT
ENSEMBL:ENSG00000101405 OXT
HGNC:8528 OXT
KEGG:hsa:5020 OXT
Monarch:5020 OXT
NCBI Gene:5020 OXT
OMIM:167050 OXT
UCSC:P01178 OXT
Reference Transcript
RefSeq:NM_000915.3 OXT
RefSeq:XM_011529238.1 OXT
Other Identifiers
11737155_at
16910959
207576_PM_x_at
207576_x_at
32472_at
3874199
3874200
3874201
3874203
3874204
5020
8060604
A_14_P102709
A_24_P382579
GE57807
GO:0001975
GO:0002027
GO:0002125
GO:0003014
GO:0005179
GO:0005184
GO:0005185
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0007165
GO:0007204
GO:0007507
GO:0007565
GO:0007613
GO:0007625
GO:0009744
GO:0010701
GO:0014070
GO:0014823
GO:0022414
GO:0030141
GO:0031410
GO:0031855
GO:0031894
GO:0032094
GO:0032308
GO:0032355
GO:0032526
GO:0032570
GO:0034695
GO:0035176
GO:0035811
GO:0042220
GO:0042711
GO:0042713
GO:0042755
GO:0042756
GO:0043195
GO:0043226
GO:0043434
GO:0045472
GO:0045776
GO:0045777
GO:0045778
GO:0045925
GO:0048018
GO:0048545
GO:0048856
GO:0050806
GO:0050877
GO:0051384
GO:0051591
GO:0051602
GO:0051965
GO:0060179
GO:0060406
GO:0060450
GO:0070474
GO:0098772
GO:0098992
GO:0120162
HMNXSV003016839
ILMN_1735124
M11186_at
PH_hs_0029103
TC20000033.hg
TC20001065.hg
g12707574_3p_at
Participates
as an input of
Oxytocin receptor bind oxytocin (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
Inferred To
Homologues of AVP(20-28) [extracellular region]
(Danio rerio)
oxt [extracellular region]
(Danio rerio)
oxt [extracellular region]
(Xenopus tropicalis)
OXT [extracellular region]
(Bos taurus)
OXT [extracellular region]
(Canis familiaris)
OXT [extracellular region]
(Gallus gallus)
OXT [extracellular region]
(Sus scrofa)
avp [extracellular region]
(Danio rerio)
Oxt [extracellular region]
(Mus musculus)
Oxt [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
XP_011527540.1
,
NP_000906.1
ENSEMBL
ENSP00000217386
,
ENST00000217386
OpenTargets
ENSG00000101405
HPA
ENSG00000101405-OXT
PRO
P01178
Pharos - Targets
P01178
HMDB Protein
HMDBP01829
PDB
7QVM
,
7OTD
,
7RYC
,
7OFG
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHG0 DCDC2
0.556
3
UniProt:Q13617 CUL2
3
CUL2 [cytosol]
(R-HSA-416982)
CUL2 [nucleoplasm]
(R-HSA-1234126)
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
0.527
2
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