Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
AVPR1A [plasma membrane]
Stable Identifier
R-HSA-388484
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RecName: Full=Vasopressin V1a receptor; Short=V1aR; AltName: Full=Vascular/hepatic-type arginine vasopressin receptor; AltName: Full=Antidiuretic hormone receptor 1a; AltName: Full=AVPR V1a;
GN Name=AVPR1A; Synonyms=AVPR1;
OS Homo sapiens, V1AR_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) (Homo sapiens)
Defective AVP mutants do not bind AVPR1A,B (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Vasopressin-like receptors (Homo sapiens)
AVP(20-28) binds AVPR1A,B (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
AVPR1A,2 bind AVPR antagonists (Homo sapiens)
AVPR1A,2 [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
AVPR1A,2:AVPR antagonists [plasma membrane] (Homo sapiens)
AVPR1A,2 [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
AVPR1A,B bind desmopressin (Homo sapiens)
AVPR1A,1B:desmopressin [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
AVPR1A,B,2 bind atosiban (Homo sapiens)
AVPR1A,B, 2 [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
AVPR1A,B,2:atosiban [plasma membrane] (Homo sapiens)
AVPR1A,B, 2 [plasma membrane] (Homo sapiens)
AVPR1A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P37288 AVPR1A
Gene Names
AVPR1A, AVPR1
Chain
chain:1-418
Reference Genes
BioGPS Gene:552 AVPR1A
COSMIC (genes):AVPR1A AVPR1A
CTD Gene:552 AVPR1A
dbSNP Gene:552 AVPR1A
ENSEMBL:ENSG00000166148 AVPR1A
HGNC:895 AVPR1A
KEGG:hsa:552 AVPR1A
Monarch:552 AVPR1A
NCBI Gene:552 AVPR1A
OMIM:600821 AVPR1A
UCSC:P37288 AVPR1A
Reference Transcript
RefSeq:NM_000706.4 AVPR1A
Other Identifiers
11736614_at
11736615_s_at
11736616_at
11736617_at
16766946
206250_PM_x_at
206250_x_at
206251_PM_s_at
206251_s_at
206252_PM_s_at
206252_s_at
238835_PM_at
238835_at
242680_PM_at
242680_at
3459731
3459732
3459733
3459734
3459735
3459736
3459737
3459738
3459739
3459740
38955_at
42785_r_at
53741_at
552
7964660
A_23_P25246
A_32_P79041
GE57693
GO:0001992
GO:0002125
GO:0003013
GO:0003084
GO:0004930
GO:0005000
GO:0005080
GO:0005515
GO:0005768
GO:0005886
GO:0006091
GO:0007186
GO:0007204
GO:0007621
GO:0007625
GO:0008015
GO:0008217
GO:0008284
GO:0010460
GO:0014049
GO:0014902
GO:0016020
GO:0017046
GO:0019722
GO:0021537
GO:0022414
GO:0030139
GO:0030154
GO:0030307
GO:0031394
GO:0031410
GO:0031894
GO:0032849
GO:0032870
GO:0035176
GO:0042277
GO:0042631
GO:0042711
GO:0042713
GO:0043226
GO:0045777
GO:0045907
GO:0048856
GO:0050886
GO:0051412
GO:0051970
GO:0060089
GO:0150104
HMNXSV003004986
Hs.164214.0.A1_3p_at
Hs.2131.0.S1_3p_a_at
Hs.69297.0.A1_3p_at
ILMN_1712159
ILMN_1909468
PH_hs_0000281
PH_hs_0004096
TC12001661.hg
U19906_at
g13112054_3p_a_at
g2623229_3p_a_at
Participates
as a member of
AVPR1A,2 [plasma membrane] (Homo sapiens)
AVPR1A,B, 2 [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
Inferred To
avpr1a [plasma membrane]
(Xenopus tropicalis)
avpr1ab [plasma membrane]
(Danio rerio)
Avpr1a [plasma membrane]
(Mus musculus)
Avpr1a [plasma membrane]
(Rattus norvegicus)
AVPR1A [plasma membrane]
(Bos taurus)
AVPR1A [plasma membrane]
(Canis familiaris)
AVPR1A [plasma membrane]
(Gallus gallus)
AVPR1A [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000697.1
ZINC - World Drugs
V1AR_HUMAN
Guide to Pharmacology - Targets
366
ENSEMBL
ENSP00000299178
,
ENST00000299178
OpenTargets
ENSG00000166148
ZINC - FDA approved
V1AR_HUMAN
ZINC - Substances
V1AR_HUMAN
ZINC target
P37288
PRO
P37288
GlyGen
P37288
PDB
1YTV
ZINC - Investigational
V1AR_HUMAN
HPA
ENSG00000166148-AVPR1A
Pharos - Targets
P37288
ZINC - Predictions - Purchasable
V1AR_HUMAN
HMDB Protein
HMDBP01723
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text