Reactome | CCK [extracellular region]

CCK [extracellular region]

Stable Identifier

R-HSA-388539

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

RecName: Full=Cholecystokinin; Short=CCK; Contains: RecName: Full=Cholecystokinin-58; Short=CCK58; Contains: RecName: Full=Cholecystokinin-58 desnonopeptide; AltName: Full=, CCKN_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q99966 CITED1

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External Reference Information

External Reference

UniProt:P06307 CCK

Gene Names

CCK

Chain

signal peptide:1-20, chain:21-115, propeptide:21-44, peptide:46-103, peptide:46-94, peptide:65-103, peptide:71-103, peptide:79-103, peptide:86-103, peptide:92-103, peptide:96-103, peptide:97-103, peptide:99-103, propeptide:107-115

Reference Genes

BioGPS Gene:885 CCK

COSMIC (genes):CCK CCK

CTD Gene:885 CCK

dbSNP Gene:885 CCK

ENSEMBL:ENSG00000187094 CCK

ENSEMBL_homo_sapiens_GENE:ENSG00000187094.12 CCK

HGNC:1569 CCK

KEGG Gene (Homo sapiens):885 CCK

Monarch:885 CCK

NCBI Gene:885 CCK

OMIM:118440 CCK

Reference Transcript

Other Identifiers

11724577_a_at

16952534

205827_PM_at

205827_at

2670726

2670727

2670731

2670733

2670734

2670735

2670736

2670737

2670738

2670739

37572_at

8086391

885

GE58231

GO:0001764

GO:0005179

GO:0005184

GO:0005515

GO:0005576

GO:0005615

GO:0007165

GO:0007409

GO:0007586

GO:0023052

GO:0030154

GO:0030424

GO:0042755

GO:0048018

GO:0048856

GO:0048870

GO:0051428

GO:0098772

HMNXSV003026901

ILMN_1712943

L00354_at

TC03001318.hg

g4755130_3p_at

Participates

as an input of

Cholecystokinin receptors bind cholecystokinin (Homo sapiens)

as a member of

Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)

as a component of

CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)

Inferred To

Cck [extracellular region] (Mus musculus)

Cck [extracellular region] (Rattus norvegicus)

cck [extracellular region] (Xenopus tropicalis)

CCK [extracellular region] (Bos taurus)

CCK [extracellular region] (Canis familiaris)

CCK [extracellular region] (Gallus gallus)

CCK [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_000720.1, NP_001167609.1

OpenTargets

ENSG00000187094

GeneCards

P06307

HPA

ENSG00000187094-CCK

Ensembl

ENSP00000409124, ENSP00000379472, ENST00000334681, ENST00000434608, ENSP00000335657, ENSG00000187094, ENST00000396169

ZINC target

P06307

PRO

P06307

Pharos - Targets

P06307

PDB

8IA7, 7MBX, 7MBY, 7EZK, 7XOU, 7EZM, 7EZH

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62701 RPS4X	2	RPS4X [nucleoplasm] (R-HSA-6798713) RPS4X [cytosol] (R-HSA-72375)	0.556	3
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:C1IDX9 C1IDX9			0.556	3
IntAct:EBI-25836264 CCSB			0.556	3
UniProt:Q8NI22 MCFD2	3	MCFD2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689836) MCFD2 [ER to Golgi transport vesicle membrane] (R-HSA-1017216) MCFD2 [endoplasmic reticulum membrane] (R-HSA-5689470)	0.556	3
UniProt:Q16609 LPAL2			0.556	3
UniProt:Q5W111-2 SPRYD7			0.556	3
UniProt:Q9H2C1 LHX5			0.556	3
UniProt:O00257-3 CBX4			0.556	3
UniProt:Q9P1Q0-4 VPS54			0.556	3
UniProt:Q494V2-2 CFAP100			0.556	3
UniProt:Q6NXT2 H3C			0.556	3
UniProt:Q7L8J4 3BP5L			0.556	3
UniProt:Q9NX94 WBP1L			0.556	3
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.556	3
UniProt:P62253 UBE2G1	2	Ub-C90-UBE2G1 [cytosol] (R-HSA-8864149) UBE2G1 [cytosol] (R-HSA-947627)	0.556	3
UniProt:Q9Y3D0 CIAO2B	1	FAM96B [cytosol] (R-HSA-2161124)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q8N1A0 KT222			0.556	3
UniProt:Q66K80 RUAS1			0.556	3
UniProt:Q6DHV7-2 Q6DHV72			0.556	3
UniProt:Q15382 RHEB	2	RHEB [endosome membrane] (R-HSA-5656350) RHEB [lysosomal membrane] (R-HSA-165190)	0.556	3
IntAct:EBI-25835796 CCSB			0.556	3
UniProt:O95278-6 O952786			0.556	3
UniProt:Q9NU02 ANKE1			0.556	3
UniProt:Q9C004 SPY4			0.556	3
UniProt:P02775 PPBP	5	PPBP(55-128) [extracellular region] (R-HSA-114638) PPBP(55-128) [platelet alpha granule lumen] (R-HSA-114637) PPBP(35-128) [platelet alpha granule lumen] (R-HSA-114572) PPBP(35-128) [tertiary granule lumen] (R-HSA-6800185) PPBP(35-128) [extracellular region] (R-HSA-114573)	0.556	3
UniProt:Q6NXG1-3 Q6NXG13			0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:Q7Z3B4 NUP54	2	NUP54 [cytosol] (R-HSA-9634221) NUP54 [nuclear envelope] (R-HSA-157724)	0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	3
UniProt:Q9UK76 JUPI1			0.556	3
UniProt:Q96HR9-2 REEP6			0.556	3
UniProt:Q66PJ3-4 ARL6IP4			0.556	3
UniProt:Q9NRZ9-6 HELLS			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:Q8NFH3 NUP43	2	NUP43 [nuclear envelope] (R-HSA-157739) NUP43 [cytosol] (R-HSA-376243)	0.556	3
UniProt:P47804-3 P478043			0.556	3
UniProt:Q6DKI2 LEG9C			0.556	3
IntAct:EBI-25836274 CCSB			0.556	3
UniProt:O75409 HYPM			0.556	3
UniProt:Q8IWT0-2 ZBTB8OS			0.556	3
UniProt:Q9UJ70-2 NAGK			0.556	3
UniProt:Q92797-2 Q927972			0.556	3
UniProt:Q8IYM2 SLN12			0.556	3
UniProt:Q9NSI6-4 BRWD1			0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:Q99966 CITED1	1	CITED1 [nucleoplasm] (R-HSA-8864301)	0.556	3
UniProt:P53701 HCCS	1	HCCS [mitochondrial inner membrane] (R-HSA-9866218)	0.556	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.556	3
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.556	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.556	3
UniProt:P25208 NFYB	1	NFYB [nucleoplasm] (R-HSA-381067)	0.556	3
UniProt:P23942 PRPH2			0.556	3
UniProt:Q96JL9-2 Q96JL92			0.556	3

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