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EDNRA [plasma membrane]
Stable Identifier
R-HSA-388549
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Endothelin receptor A, RecName: Full=Endothelin-1 receptor; AltName: Full=Endothelin A receptor; Short=hET-AR; Short=ETA-R; Short=ET-A; Flags: Precursor; GN Name=EDNRA; Synonyms=ETA, ETRA; OS Homo sapiens, EDNRA_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
EDNRA binds EDNs (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
EDNRA:EDNs [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
EDNRA binds selective ERAs (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
EDNRA:selective ERAs [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
EDNRA, EDNRB bind non-selective ERAs (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
EDNRA,EDNRB bind EDNs (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25101 EDNRA
Gene Names
EDNRA, ETA, ETRA
Chain
signal peptide:1-20, chain:21-427
Reference Genes
BioGPS Gene:1909 EDNRA
COSMIC (genes):EDNRA EDNRA
CTD Gene:1909 EDNRA
dbSNP Gene:1909 EDNRA
ENSEMBL:ENSG00000151617 EDNRA
ENSEMBL_homo_sapiens_GENE:ENSG00000151617.17 EDNRA
HGNC:3179 EDNRA
KEGG Gene (Homo sapiens):1909 EDNRA
Monarch:1909 EDNRA
NCBI Gene:1909 EDNRA
OMIM:131243 EDNRA
UCSC:P25101 EDNRA
Reference Transcript
RefSeq:NM_001957.3 EDNRA
RefSeq:NM_001166055.1 EDNRA
RefSeq:NM_001256283.1 EDNRA
Other Identifiers
11719488_at
11719489_a_at
11747876_a_at
1507_s_at
16971272
1909
204463_PM_s_at
204463_s_at
204464_PM_s_at
204464_s_at
216235_PM_s_at
216235_s_at
2746596
2746597
2746598
2746601
2746602
2746603
2746618
2746623
2746624
2746625
2746627
2746628
2746632
2746633
8097692
A_14_P132706
A_23_P7337
A_24_P217572
A_33_P3401701
D11151_at
GE59872
GO:0000278
GO:0001525
GO:0001569
GO:0001666
GO:0001701
GO:0001974
GO:0001975
GO:0002027
GO:0003012
GO:0003013
GO:0003014
GO:0003015
GO:0003094
GO:0003207
GO:0003220
GO:0003228
GO:0003253
GO:0003357
GO:0003824
GO:0004435
GO:0004930
GO:0004962
GO:0005515
GO:0005886
GO:0006790
GO:0006874
GO:0006939
GO:0007005
GO:0007165
GO:0007186
GO:0007190
GO:0007193
GO:0007202
GO:0007204
GO:0007411
GO:0007507
GO:0007585
GO:0008015
GO:0008217
GO:0008283
GO:0009611
GO:0010033
GO:0010467
GO:0010737
GO:0010827
GO:0012501
GO:0014032
GO:0014033
GO:0014034
GO:0014824
GO:0016020
GO:0016322
GO:0016787
GO:0022414
GO:0023052
GO:0030154
GO:0030202
GO:0030878
GO:0031175
GO:0032835
GO:0034599
GO:0035050
GO:0035556
GO:0035904
GO:0042310
GO:0042415
GO:0042474
GO:0043123
GO:0044751
GO:0048066
GO:0048484
GO:0048485
GO:0048675
GO:0048706
GO:0048856
GO:0048870
GO:0050877
GO:0050905
GO:0055065
GO:0055078
GO:0055085
GO:0060070
GO:0060089
GO:0060322
GO:0060324
GO:0060385
GO:0061028
GO:0061626
GO:0065008
GO:0070294
GO:0070588
GO:0071310
GO:0071372
GO:0071373
GO:0071806
GO:0071944
GO:0072011
GO:0072112
GO:0086100
GO:0086101
GO:0097018
GO:0097084
GO:0097152
GO:0097492
GO:1901135
GO:1902287
GO:1903210
GO:1903537
GO:1904888
GO:1905144
GO:1905871
GO:2001259
HMNXSV003000313
Hs.76252.0.S2_3p_a_at
Hs.76252.1.S1_3p_a_at
ILMN_1796629
PH_hs_0023071
TC04000729.hg
TC04002255.hg
g4503464_3p_a_at
Participates
as a component of
EDNRA:selective ERAs [plasma membrane] (Homo sapiens)
EDNRA:EDNs [plasma membrane] (Homo sapiens)
as an input of
EDNRA binds selective ERAs (Homo sapiens)
EDNRA binds EDNs (Homo sapiens)
as a member of
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
Inferred To
Ednra [plasma membrane]
(Mus musculus)
Ednra [plasma membrane]
(Rattus norvegicus)
EDNRA [plasma membrane]
(Bos taurus)
EDNRA [plasma membrane]
(Canis familiaris)
EDNRA [plasma membrane]
(Gallus gallus)
EDNRA [plasma membrane]
(Sus scrofa)
ednra [plasma membrane]
(Xenopus tropicalis)
ednraa [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001948.1
,
NP_001243212.1
,
NP_001159527.1
ZINC - World Drugs
EDNRA_HUMAN
Guide to Pharmacology - Targets
219
OpenTargets
ENSG00000151617
ZINC - FDA approved
EDNRA_HUMAN
ZINC - Substances
EDNRA_HUMAN
ZINC target
P25101
PRO
P25101
PDB
8HCQ
ZINC - Investigational
EDNRA_HUMAN
HPA
ENSG00000151617-EDNRA
GeneCards
P25101
Ensembl
ENSP00000496976
,
ENSP00000498969
,
ENSG00000151617
,
ENST00000506066
,
ENST00000510697
,
ENST00000648866
,
ENSP00000315011
,
ENSP00000425281
,
ENSP00000427259
,
ENSP00000425354
,
ENST00000511804
,
ENST00000324300
,
ENST00000358556
,
ENST00000651419
,
ENSP00000351359
Pharos - Targets
P25101
Orphanet
23587
ZINC - Predictions - Purchasable
EDNRA_HUMAN
HMDB Protein
HMDBP02261
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96KC2 ARL5B
0.527
2
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.527
2
UniProt:O43760 SNG2
0.527
2
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.527
2
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.499
2
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
3
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