Reactome | PTPRA [plasma membrane]

PTPRA [plasma membrane]

Stable Identifier

R-HSA-388755

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Receptor-type tyrosine-protein phosphatase alpha, PTPRA_HUMAN

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Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
        
        PTPRA [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18433 PTPRA

Gene Names

PTPRA, PTPA, PTPRL2

Chain

signal peptide:1-19, chain:20-802

Reference Genes

BioGPS Gene:5786 PTPRA

COSMIC (genes):PTPA PTPRA

COSMIC (genes):PTPRA PTPRA

CTD Gene:5786 PTPRA

dbSNP Gene:5786 PTPRA

ENSEMBL:ENSG00000132670 PTPRA

HGNC:9664 PTPRA

KEGG:hsa:5786 PTPRA

Monarch:5786 PTPRA

NCBI Gene:5786 PTPRA

OMIM:176884 PTPRA

UCSC:P18433 PTPRA

Reference Transcript

Other Identifiers

11742217_a_at

11746947_a_at

11749026_a_at

1496_at

213795_PM_s_at

213795_s_at

213799_3p_s_at

213799_PM_s_at

213799_s_at

239419_PM_at

239419_at

3874073

3874074

3874075

3874076

3874092

3874093

3874096

3874101

3874102

3874103

3874104

3874105

3874114

3874115

3874116

3874118

3874126

3874127

3874128

3874129

3874133

3874134

3874135

3874137

3874140

3874142

3874143

3874144

3874147

3874155

3874156

3874158

3874160

3874161

3874162

3874163

3874164

3874165

5786

73216_r_at

83463_at

A_14_P122774

A_14_P135265

A_23_P28869

GE57944

GO:0003824

GO:0004721

GO:0004725

GO:0005001

GO:0005515

GO:0005886

GO:0005925

GO:0006470

GO:0007229

GO:0008286

GO:0016020

GO:0016311

GO:0016787

GO:0043226

GO:0043235

GO:0050804

GO:0051893

GO:0060089

GO:0070062

GO:0070161

GO:0097060

GO:0098685

GO:0140096

HMNXSV003037716

Hs.154004.0.A1_3p_at

Hs.26045.1.S1_3p_a_at

Hs.26045.1.S1_3p_s_at

Hs.26045.1.S2_3p_a_at

ILMN_1695461

ILMN_1762766

ILMN_2296776

ILMN_2411794

M34668_at

TC20001064.hg

TC20001728.hg

p26769

Participates

as an input of

Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)

as a component of

Inferred To

Ptp52F [plasma membrane] (Drosophila melanogaster)

PTPRA [plasma membrane] (Bos taurus)

PTPRA [plasma membrane] (Caenorhabditis elegans)

PTPRA [plasma membrane] (Canis familiaris)

PTPRA [plasma membrane] (Drosophila melanogaster)

PTPRA [plasma membrane] (Gallus gallus)

PTPRA [plasma membrane] (Mus musculus)

PTPRA [plasma membrane] (Rattus norvegicus)

PTPRA [plasma membrane] (Sus scrofa)

PTPRA [plasma membrane] (Xenopus tropicalis)

Homologues of PTPRA [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_002827.1, NP_543030.1, NP_543031.1

Guide to Pharmacology - Targets

1850

OpenTargets

ENSG00000132670

ENSEMBL

ENST00000216877, ENSP00000348468, ENSP00000216877, ENST00000399903, ENSP00000382787, ENSP00000314568, ENST00000318266, ENST00000356147

ZINC - Substances

PTPRA_HUMAN

ZINC target

P18433

PRO

P18433

GlyGen

P18433

PDB

6UZT

HPA

ENSG00000132670-PTPRA

Pharos - Targets

P18433

ZINC - Predictions - Purchasable

PTPRA_HUMAN

HMDB Protein

HMDBP02719

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.934	16
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.734	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:P00523 SRC	9	SRC-2 [cytosol] (R-GGA-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-GGA-1810408) SRC-1 [plasma membrane] (R-GGA-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-GGA-377598) phospho-p-Y419-SRC [cytosol] (R-GGA-377592) MyrG-SRC [plasma membrane] (R-GGA-8876922) Src [cytosol] (R-GGA-3928468) phospho-p-Y419-SRC [cytosol] (R-GGA-8964276) SRC [cytosol] (R-GGA-9628701)	0.59	4
UniProt:P23469 PTPRE			0.527	3
UniProt:P49447 CY561			0.527	3
UniProt:O00602 FCN1	3	FCN1 [ficolin-1-rich granule lumen] (R-HSA-6801473) FCN1 [secretory granule lumen] (R-HSA-6801474) FCN1 [extracellular region] (R-HSA-2530451)	0.527	2
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.527	3
UniProt:Q8NHX9 TPCN2	1	TPCN2 [lysosomal membrane] (R-HSA-2685518)	0.527	2
UniProt:Q02446 SP4			0.527	2
UniProt:O00214 LEG8			0.527	3
UniProt:Q8IXK2 GALNT12	6	GALNT12 Y395* [Golgi membrane] (R-HSA-5138160) GALNT12 M1I [Golgi membrane] (R-HSA-5138151) GALNT12 Y396C [Golgi membrane] (R-HSA-5138168) GALNT12 D303N [Golgi membrane] (R-HSA-5138141) GALNT12 T491M [Golgi membrane] (R-HSA-5138143) GALNT12 [Golgi membrane] (R-HSA-913627)	0.527	3
UniProt:Q9NWL6 ASND1			0.527	2
UniProt:Q7Z401 DENND4A	1	DENND4A [cytosol] (R-HSA-8876072)	0.527	2
UniProt:P39688 Fyn	6	Fyn [cytosol] (R-MMU-420333) phospho-MyrG-p-Y420-FYN-1 [plasma membrane] (R-MMU-9032530) pFyn (420) [cytosol] (R-MMU-420335) pFyn(Y531) [cytosol] (R-MMU-420350) MyrG,p-Y420-Fyn [plasma membrane] (R-MMU-9037733) phospho-p-S21,Y420-FYN [cytosol] (R-MMU-5218745)	0.524	2
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.509	2
UniProt:P14781 CNTN1	1	CNTN1_CHICK [plasma membrane] (R-GGA-443614)	0.463	2

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