Reactome | CD28 homodimer binds B7-1 homodimer

CD28 homodimer binds B7-1 homodimer

Stable Identifier

R-HSA-388811

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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A costimulatory signal involved in T cell activation is transmitted by CD28. This signal is delivered by the interaction of the CD28 receptor on T cells with its ligand B7-1 on the antigen-presenting cell and modulates T cell antigen recognition. Despite the homodimeric structure of CD28, it interacts with B7-1 as though it has a single binding site. The V-like domains of CD28 contains a strictly conserved MYPPPY sequence motif that maps to the CDR3-analogous loop and is critical for recognition of its ligands. B7-1 and B7-2 bind to overlapping but not identical sites on CD28

Literature References

PubMed ID	Title	Journal	Year
8649453	Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis Couez, D, Olive, D, Hurle, MR, Eichman, C, Sweet, R, Lyn, SD, Ryan, P, Sekaly, RP, Reddy, M, Truneh, A	Mol Immunol	1996
8609386	Interactions of CD80 and CD86 with CD28 and CTLA4 Crowe, JS, Vinogradov, DV, Linge, C, Ellis, JH, Burden, MN	J Immunol	1996