PI3K binds ICOS

Stable Identifier
R-HSA-388830
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PI3K binds ICOS
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The p85 unit of PI3K is the only signaling molecule identified so far that interacts with ICOS. ICOS contains several conserved motifs also found in CD28, including the YxxM motif in the cytoplasmic tail, which binds the lipid kinase phosphatidylinositol 3-kinase (PI3K) upon tyrosine phosphorylation after complex formation with ICOS. However, ICOS costimulation shows greater PI3K activity than CD28 in T cells.
Literature References
PubMed ID Title Journal Year
12538664 A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)

Tanabe, K, Koiwai, O, Okano, K, Harada, Y, Toma, H, Abe, R, Altman, A, Watanabe, R, Ohgai, D

J Exp Med 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ICOS:ICOSL [plasma membrane] (Homo sapiens)
Orthologous Events
PI3K binds ICOS (Bos taurus)
PI3K binds ICOS (Canis familiaris)
PI3K binds ICOS (Gallus gallus)
PI3K binds ICOS (Mus musculus)
PI3K binds ICOS (Rattus norvegicus)
PI3K binds ICOS (Sus scrofa)
PI3K binds ICOS (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-16)
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