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NPY [extracellular region]
Stable Identifier
R-HSA-388906
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Neuropeptide Y, NPY(29-64), RecName: Full=Neuropeptide Y; Contains: RecName: Full=Neuropeptide Y; AltName: Full=Neuropeptide tyrosine; Short=NPY; Contains: RecName: Full=C-flanking peptide of NPY; Short=CPON; Flags: Precursor;
GN Name=NPY;
OS Homo sapiens, NPY_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
NPY gene expression is stimulated by FOXO1 (Homo sapiens)
NPY [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
NPY receptor ligands [extracellular region] (Homo sapiens)
NPY [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
NPY receptor ligands [extracellular region] (Homo sapiens)
NPY [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
NPY receptor ligands [extracellular region] (Homo sapiens)
NPY [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
NPY receptor ligands [extracellular region] (Homo sapiens)
NPY [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
NPY receptor ligands [extracellular region] (Homo sapiens)
NPY [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
NPY receptor ligands [extracellular region] (Homo sapiens)
NPY [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)
NPY receptor ligands [extracellular region] (Homo sapiens)
NPY [extracellular region] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
NPY receptor ligands [extracellular region] (Homo sapiens)
NPY [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01303 NPY
Gene Names
NPY
Chain
signal peptide:1-28, peptide:29-64, peptide:68-97
Reference Genes
BioGPS Gene:4852 NPY
COSMIC (genes):NPY NPY
CTD Gene:4852 NPY
dbSNP Gene:4852 NPY
ENSEMBL:ENSG00000122585 NPY
ENSEMBL_homo_sapiens_GENE:ENSG00000122585.8 NPY
HGNC:7955 NPY
KEGG Gene (Homo sapiens):4852 NPY
Monarch:4852 NPY
NCBI Gene:4852 NPY
OMIM:162640 NPY
UCSC:P01303 NPY
Reference Transcript
RefSeq:NM_000905.3 NPY
Other Identifiers
11757560_a_at
17044372
206001_PM_at
206001_at
2993137
2993139
2993140
2993141
2993142
2993146
2993152
2993153
38604_at
4852
8131919
A_23_P256470
GE57534
GO:0001664
GO:0003013
GO:0004930
GO:0005102
GO:0005179
GO:0005184
GO:0005246
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005794
GO:0007187
GO:0007218
GO:0007268
GO:0007631
GO:0008217
GO:0008343
GO:0021954
GO:0021987
GO:0023052
GO:0030154
GO:0031175
GO:0031410
GO:0031841
GO:0032100
GO:0043226
GO:0048018
GO:0048856
GO:0060089
GO:0060575
GO:0098772
GO:0098982
GO:0098992
GO:0099538
HMNXSV003011068
ILMN_1731062
K01911_at
PH_hs_0000245
TC07000153.hg
g4505448_3p_at
Participates
as an output of
NPY gene expression is stimulated by FOXO1 (Homo sapiens)
as a member of
NPY receptor ligands [extracellular region] (Homo sapiens)
Inferred To
NPY [extracellular region]
(Bos taurus)
NPY [extracellular region]
(Canis familiaris)
NPY [extracellular region]
(Gallus gallus)
NPY [extracellular region]
(Sus scrofa)
npy [extracellular region]
(Danio rerio)
npy [extracellular region]
(Xenopus tropicalis)
Npy [extracellular region]
(Mus musculus)
Npy [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000896.1
OpenTargets
ENSG00000122585
GeneCards
P01303
HPA
ENSG00000122585-NPY
Ensembl
ENST00000242152
,
ENSP00000384364
,
ENSP00000385282
,
ENSP00000242152
,
ENST00000405982
,
ENSG00000122585
,
ENST00000407573
PRO
P01303
Pharos - Targets
P01303
Orphanet
25739
PDB
7YOO
,
7X9B
,
1RON
,
7RTA
,
7X9A
,
7VGX
,
1QFA
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:F1D8P7 F1D8P7
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
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