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NTSR2 [plasma membrane]
Stable Identifier
R-HSA-388918
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RecName: Full=Neurotensin receptor type 2; AltName: Full=NTR2 receptor; Short=NT-R-2; AltName: Full=Levocabastine-sensitive neurotensin receptor; GN Name=NTSR2; OS Homo sapiens, NTR2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR2 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Neurotensin receptors can bind neurotensins (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR2 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95665 NTSR2
Gene Names
NTSR2
Chain
chain:1-410
Reference Genes
BioGPS Gene:23620 NTSR2
COSMIC (genes):NTSR2 NTSR2
CTD Gene:23620 NTSR2
dbSNP Gene:23620 NTSR2
ENSEMBL:ENSG00000169006 NTSR2
ENSEMBL_homo_sapiens_GENE:ENSG00000169006.7 NTSR2
HGNC:8040 NTSR2
KEGG Gene (Homo sapiens):23620 NTSR2
Monarch:23620 NTSR2
NCBI Gene:23620 NTSR2
OMIM:605538 NTSR2
UCSC:O95665 NTSR2
Reference Transcript
RefSeq:NM_012344.3 NTSR2
Other Identifiers
11731701_a_at
16894559
206899_PM_at
206899_at
23620
2540659
2540660
2540661
2540664
2540671
2540672
2540673
2540677
2540678
2540679
2540680
2540681
2540682
2540683
2540684
33011_at
8050352
A_23_P315212
GE79715
GO:0004930
GO:0005886
GO:0007165
GO:0007166
GO:0007186
GO:0007200
GO:0007218
GO:0007600
GO:0016020
GO:0016492
GO:0023052
GO:0042391
GO:0050877
GO:0060089
HMNXSV003019689
ILMN_1685719
ILMN_1761280
PH_hs_0007755
TC02001582.hg
g6912537_3p_at
Participates
as a member of
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
Inferred To
ntsr2 [plasma membrane]
(Xenopus tropicalis)
PK2-R1 [plasma membrane]
(Drosophila melanogaster)
nmur-1 [plasma membrane]
(Caenorhabditis elegans)
NTSR2 [plasma membrane]
(Bos taurus)
NTSR2 [plasma membrane]
(Caenorhabditis elegans)
NTSR2 [plasma membrane]
(Canis familiaris)
NTSR2 [plasma membrane]
(Sus scrofa)
nmur-2 [plasma membrane]
(Caenorhabditis elegans)
Ntsr2 [plasma membrane]
(Mus musculus)
Ntsr2 [plasma membrane]
(Rattus norvegicus)
ntsr1 [plasma membrane]
(Danio rerio)
Homologues of NTSR2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of NTSR2 [plasma membrane]
(Drosophila melanogaster)
npr-20 [plasma membrane]
(Caenorhabditis elegans)
PK1-R [plasma membrane]
(Drosophila melanogaster)
CapaR [plasma membrane]
(Drosophila melanogaster)
PK2-R2 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_036476.1
Guide to Pharmacology - Targets
310
OpenTargets
ENSG00000169006
ZINC - Substances
NTR2_HUMAN
ZINC target
O95665
PRO
O95665
ZINC - Investigational
NTR2_HUMAN
HPA
ENSG00000169006-NTSR2
GeneCards
O95665
Ensembl
ENST00000306928
,
ENSG00000169006
,
ENSP00000303686
Pharos - Targets
O95665
ZINC - Predictions - Purchasable
NTR2_HUMAN
HMDB Protein
HMDBP07854
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