Reactome | GAL [extracellular region]

GAL [extracellular region]

Stable Identifier

R-HSA-389038

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Galanin, RecName: Full=Galanin; Contains: RecName: Full=Galanin; Contains: RecName: Full=Galanin message-associated peptide; Short=GMAP; Flags: Precursor;
GN Name=GAL; Synonyms=GAL1, GALN, GLNN;
OS Homo sapiens, GALA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22466 GAL

Gene Names

GAL, GAL1, GALN, GLNN

Chain

signal peptide:1-19, propeptide:20-30, peptide:33-62, peptide:65-123

Reference Genes

BioGPS Gene:51083 GAL

COSMIC (genes):GAL GAL

CTD Gene:51083 GAL

dbSNP Gene:51083 GAL

ENSEMBL:ENSG00000069482 GAL

ENSEMBL_homo_sapiens_GENE:ENSG00000069482.7 GAL

HGNC:4114 GAL

KEGG Gene (Homo sapiens):51083 GAL

Monarch:51083 GAL

NCBI Gene:51083 GAL

OMIM:137035 GAL

UCSC:P22466 GAL

Reference Transcript

RefSeq:NM_015973.4 GAL

Other Identifiers

11725749_a_at

11725750_at

16728141

214240_PM_at

214240_at

3337760

3337761

3337762

3337763

3337765

3337767

3337768

3337769

35879_at

51083

7942064

A_23_P374844

A_33_P3269976

GE58081

GO:0002376

GO:0004966

GO:0005179

GO:0005184

GO:0005515

GO:0005576

GO:0005615

GO:0006351

GO:0006355

GO:0006629

GO:0007218

GO:0007631

GO:0008285

GO:0009410

GO:0010737

GO:0012501

GO:0019933

GO:0023052

GO:0030073

GO:0030141

GO:0031410

GO:0031763

GO:0031764

GO:0031765

GO:0031766

GO:0031943

GO:0032868

GO:0035902

GO:0043025

GO:0043065

GO:0043226

GO:0043627

GO:0045944

GO:0048018

GO:0048856

GO:0050672

GO:0050886

GO:0051464

GO:0051795

GO:0055085

GO:0060089

GO:0098772

GO:1902608

HMNXSV003029467

HMNXSV003049907

Hs.1907.0.S1_3p_at

ILMN_1682015

M77140_at

PH_hs_0014331

TC11000709.hg

g7705741_3p_s_at

Participates

as an input of

Galanin receptors can bind galanin (Homo sapiens)

as a component of

GALR1-3:GAL [plasma membrane] (Homo sapiens)

Inferred To

GAL [extracellular region] (Bos taurus)

GAL [extracellular region] (Canis familiaris)

GAL [extracellular region] (Gallus gallus)

GAL [extracellular region] (Sus scrofa)

Gal [extracellular region] (Mus musculus)

Gal [extracellular region] (Rattus norvegicus)

LOC100491634 [extracellular region] (Xenopus tropicalis)

gal [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_057057.2

OpenTargets

ENSG00000069482

HPA

ENSG00000069482-GAL

GeneCards

P22466

Ensembl

ENSP00000265643, ENST00000265643, ENSG00000069482

PRO

P22466

Pharos - Targets

P22466

PDB

7S3O, 7XJJ, 7XJK, 8DJ4, 7WQ4, 7S3R, 7S3Q, 7WQ3, 7XBD, 8DHZ

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.718	6
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.556	3
UniProt:P35520 CBS	1	PXLP-K119-CBS [cytosol] (R-HSA-1614563)	0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:P23560-2 BDNF			0.556	3
UniProt:Q12797-6 ASPH			0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P55899 FCGRN			0.527	2
UniProt:Q9UBM8 MGAT4C	1	MGAT4C [Golgi membrane] (R-HSA-975907)	0.527	2
UniProt:P09238 MMP10	2	MMP10 [extracellular region] (R-HSA-1442488) MMP10(18-476) [extracellular region] (R-HSA-1604748)	0.527	2