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LIN37 [nucleoplasm]
Stable Identifier
R-HSA-389101
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lin-37
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex binds the CDC25A gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex binds the CDC6 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex binds the E2F1 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex binds the PCNA gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex binds the RBL1 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:RBL1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex binds the TOP2A gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:TOP2A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:RBL1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:TOP2A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
p130 (RBL2) associates with MuvB to form DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Polo-like kinase mediated events (Homo sapiens)
FOXM1 binds CCNB1 promoter (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
FOXM1 binds CCNB2 promoter (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB2 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
FOXM1 binds PLK1 promoter (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:PLK1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
FOXM1 stimulates CCNB1 transcription (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
FOXM1 stimulates CCNB2 transcription (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB2 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
FOXM1 stimulates PLK1 transcription (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:PLK1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN37 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96GY3 LIN37
Gene Names
LIN37, MSTP064
Chain
chain:1-246
Reference Genes
BioGPS Gene:55957 LIN37
COSMIC (genes):LIN37 LIN37
CTD Gene:55957 LIN37
dbSNP Gene:55957 LIN37
ENSEMBL:ENSG00000267796 LIN37
HGNC:33234 LIN37
KEGG:hsa:55957 LIN37
Monarch:55957 LIN37
NCBI Gene:55957 LIN37
UCSC:Q96GY3 LIN37
Reference Transcript
RefSeq:NM_019104.2 LIN37
Other Identifiers
11746235_a_at
11746236_a_at
16861200
213526_PM_s_at
213526_s_at
232534_PM_at
232534_at
35993_s_at
35994_at
3830803
3830804
3830805
3830808
3830809
3830810
3830811
3830812
3830813
3830814
3830815
3830816
3830817
3830818
3830819
3830820
3830821
3830822
3830823
3830824
55957
8028004
A_14_P118784
A_23_P165186
GO:0000122
GO:0005515
GO:0005654
GO:0006355
GO:0017053
GO:0031523
HMNXSV003004298
Hs.283522.0.A1_3p_at
Hs.42514.0.S1_3p_a_at
ILMN_1656886
PH_hs_0025049
TC19002631.hg
p8703
Participates
as a component of
p-MuvB complex [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
Inferred To
LIN37 [nucleoplasm]
(Bos taurus)
LIN37 [nucleoplasm]
(Canis familiaris)
LIN37 [nucleoplasm]
(Sus scrofa)
lin37 [nucleoplasm]
(Danio rerio)
lin37 [nucleoplasm]
(Xenopus tropicalis)
Lin37 [nucleoplasm]
(Mus musculus)
Lin37 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of LIN37 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of LIN37 [nucleoplasm]
(Gallus gallus)
mip40 [nucleoplasm]
(Drosophila melanogaster)
lin-37 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_061977.1
ENSEMBL
ENST00000301159
,
ENSP00000301159
OpenTargets
ENSG00000267796
HPA
ENSG00000267796-LIN37
PRO
Q96GY3
Pharos - Targets
Q96GY3
GlyGen
Q96GY3
PDB
7R1D
,
7N40
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.725
4
UniProt:Q08999 RBL2
2
RBL2 [nucleoplasm]
(R-HSA-389102)
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
0.702
13
UniProt:P10243 MYBL1
1
MYBL1 [nucleoplasm]
(R-HSA-389109)
0.643
4
UniProt:P10244 MYBL2
1
MYBL2 [nucleoplasm]
(R-HSA-389106)
0.643
6
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.527
2
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.527
2
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