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PHC3 [nucleoplasm]
Stable Identifier
R-HSA-389116
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
E2F6 binds the PRC1 complex (Homo sapiens)
E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
PHC1,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
PHC1,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA methylation proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NDX5 PHC3
Gene Names
PHC3, EDR3, PH3
Chain
chain:1-983
Reference Genes
BioGPS Gene:80012 PHC3
COSMIC (genes):PHC3 PHC3
CTD Gene:80012 PHC3
dbSNP Gene:80012 PHC3
ENSEMBL:ENSG00000173889 PHC3
HGNC:15682 PHC3
KEGG:hsa:80012 PHC3
Monarch:80012 PHC3
NCBI Gene:80012 PHC3
OMIM:620031 PHC3
UCSC:Q8NDX5 PHC3
Reference Transcript
RefSeq:NM_024947.3 PHC3
RefSeq:NM_001308116.1 PHC3
Other Identifiers
11722279_a_at
11722280_at
11722281_a_at
11747142_a_at
11752039_a_at
11752040_s_at
11759919_at
11759920_at
1552644_PM_a_at
1552644_a_at
16961420
215521_PM_at
215521_at
220328_PM_at
220328_at
226508_PM_at
226508_at
238693_PM_at
238693_at
2704883
2704885
2704887
2704889
2704891
2704893
2704895
2704896
2704897
2704898
2704899
2704900
2704901
2704902
2704906
2704908
2704909
2704910
2704911
2704912
2704913
2704914
2704915
2704916
2704917
2704919
2704920
2704925
2704926
2704927
2704928
2704929
2704932
2704933
2704934
2704935
2704937
2704938
2704940
2704941
2704945
2704947
43936_at
57819_at
66503_at
80012
8092035
87668_at
A_23_P409988
A_24_P179175
A_24_P265177
A_33_P3400324
GE691709
GE782232
GE83015
GE88636
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0008270
GO:0031519
GO:0032991
GO:0035102
GO:0042393
GO:0043226
GO:0045892
GO:0046872
HMNXSV003046344
HMNXSV003046737
Hs.231977.1.S1_3p_at
Hs.25328.0.A1_3p_at
Hs.97042.0.A1_3p_at
Hs2.231977.1.S1_3p_a_at
ILMN_2179873
TC03001988.hg
TC03003204.hg
g13489102_3p_at
Participates
as a component of
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
as a member of
PHC1,PHC3 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
Inferred To
phc3 [nucleoplasm]
(Xenopus tropicalis)
Homologues of PHC3 [nucleoplasm]
(Drosophila melanogaster)
Phc3 [nucleoplasm]
(Rattus norvegicus)
ph-d [nucleoplasm]
(Drosophila melanogaster)
PHC3 [nucleoplasm]
(Bos taurus)
PHC3 [nucleoplasm]
(Canis familiaris)
PHC3 [nucleoplasm]
(Drosophila melanogaster)
PHC3 [nucleoplasm]
(Gallus gallus)
PHC3 [nucleoplasm]
(Mus musculus)
PHC3 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_079223.3
,
NP_001295045.1
ENSEMBL
ENST00000495893
,
ENSP00000420271
,
ENSP00000420294
,
ENST00000494943
,
ENSP00000420454
,
ENST00000497658
OpenTargets
ENSG00000173889
HPA
ENSG00000173889-PHC3
PRO
Q8NDX5
Pharos - Targets
Q8NDX5
GlyGen
Q8NDX5
PDB
4PZO
,
4PZN
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.725
6
UniProt:O15294 OGT
2
OGT [nucleoplasm]
(R-HSA-3321845)
OGT [cytosol]
(R-HSA-9687814)
0.556
3
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
0.483
2
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