Reactome | CBX8 [nucleoplasm]

CBX8 [nucleoplasm]

Stable Identifier

R-HSA-389117

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX8 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX8 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN gene transcription (Homo sapiens)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX8 [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX8 [nucleoplasm] (Homo sapiens)
        
        PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX8 [nucleoplasm] (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HC52 CBX8

Gene Names

CBX8, PC3, RC1

Chain

chain:1-389

Reference Genes

BioGPS Gene:57332 CBX8

COSMIC (genes):CBX8 CBX8

CTD Gene:57332 CBX8

dbSNP Gene:57332 CBX8

ENSEMBL:ENSG00000141570 CBX8

HGNC:15962 CBX8

KEGG:hsa:57332 CBX8

Monarch:57332 CBX8

NCBI Gene:57332 CBX8

OMIM:617354 CBX8

UCSC:Q9HC52 CBX8

Reference Transcript

RefSeq:NM_020649.2 CBX8

Other Identifiers

11727952_at

16849625

219755_PM_at

219755_at

3773148

3773150

3773151

3773152

3773153

3773154

3773155

3773156

3773157

3773158

3773159

3773160

3773161

3773163

3773165

57332

8019010

A_23_P55421

GE561501

GE62516

GO:0000122

GO:0000785

GO:0000792

GO:0003682

GO:0003723

GO:0003727

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006355

GO:0008284

GO:0031519

GO:0032967

GO:0035064

GO:0035102

GO:0042393

GO:0043226

GO:0045739

GO:0070301

GO:0097027

GO:0098772

HMNXSV003001077

ILMN_1775183

PH_hs_0024577

TC17001929.hg

g10190681_3p_at

Participates

as a component of

as a member of

Inferred To

CBX8 [nucleoplasm] (Bos taurus)

CBX8 [nucleoplasm] (Canis familiaris)

CBX8 [nucleoplasm] (Gallus gallus)

CBX8 [nucleoplasm] (Sus scrofa)

Pc [nucleoplasm] (Drosophila melanogaster)

cbx8 [nucleoplasm] (Xenopus tropicalis)

Cbx8 [nucleoplasm] (Mus musculus)

Cbx8 [nucleoplasm] (Rattus norvegicus)

cbx8b [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_065700.1

ENSEMBL

ENST00000269385, ENSP00000269385

OpenTargets

ENSG00000141570

HPA

ENSG00000141570-CBX8

ZINC - Substances

CBX8_HUMAN

ZINC target

Q9HC52

PRO

Q9HC52

Pharos - Targets

Q9HC52

GlyGen

Q9HC52

ZINC - Predictions - Purchasable

CBX8_HUMAN

PDB

3I91, 2N4Q, 5EQ0

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.926	13
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.784	5
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.718	6
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.623	7
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.573	2
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:P42568 MLLT3	1	MLLT3 [nucleoplasm] (R-HSA-8932789)	0.544	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2