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CBX4 [nucleoplasm]
Stable Identifier
R-HSA-389118
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA methylation proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)
CBX4, UHRF2 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00257 CBX4
Gene Names
CBX4
Chain
chain:1-560
Reference Genes
COSMIC (genes):CBX4 CBX4
dbSNP Gene:8535 CBX4
ENSEMBL:ENSG00000141582 CBX4
Participates
as a member of
CBX4, UHRF2 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
as a component of
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K494-CBX4 [nucleoplasm]
Inferred To
Cbx4 [nucleoplasm]
(Mus musculus)
Cbx4 [nucleoplasm]
(Rattus norvegicus)
cbx4 [nucleoplasm]
(Xenopus tropicalis)
cbx7a [nucleoplasm]
(Danio rerio)
CBX4 [nucleoplasm]
(Bos taurus)
CBX4 [nucleoplasm]
(Canis familiaris)
CBX4 [nucleoplasm]
(Gallus gallus)
CBX4 [nucleoplasm]
(Sus scrofa)
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.788
7
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
0.695
5
UniProt:Q16665 HIF1A
7
HIF1A [nucleoplasm]
(R-HSA-1234135)
HIF1A [cytosol]
(R-HSA-1234102)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
HN-HIF1A [cytosol]
(R-HSA-1234110)
0.674
15
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.643
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.604
3
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
SUMO1 [nucleoplasm]
(R-HSA-877304)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
0.602
4
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