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RNF2 [nucleoplasm]
Stable Identifier
R-HSA-389119
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RING2, E3 ubiquitin-protein ligase RING2, RING1B
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
CDC7 gene expression is repressed by the PRC1L4 complex (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1L4:CDC7 gene [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1.6 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
E2F6 forms the PRC1L4 complex (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
The PRC1L4 complex binds the CDC7 gene promoter (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1L4:CDC7 gene [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
The PRC1L4 complex binds the UXT gene promoter (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1L4:UXT gene [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
UXT gene expression is repressed by the PRC1L4 complex (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1L4:UXT gene [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1.5 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1.5 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA methylation proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RNF2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99496 RNF2
Gene Names
RNF2, BAP1, DING, HIPI3, RING1B
Chain
initiator methionine:, chain:2-336
Reference Genes
BioGPS Gene:6045 RNF2
COSMIC (genes):RNF2 RNF2
CTD Gene:6045 RNF2
dbSNP Gene:6045 RNF2
ENSEMBL:ENSG00000121481 RNF2
ENSEMBL_homo_sapiens_GENE:ENSG00000121481.11 RNF2
HGNC:10061 RNF2
Monarch:6045 RNF2
NCBI Gene:6045 RNF2
OMIM:608985 RNF2
UCSC:Q99496 RNF2
Reference Transcript
RefSeq:NM_007212.3 RNF2
RefSeq:XM_011509852.2 RNF2
RefSeq:XM_011509851.2 RNF2
Other Identifiers
11728230_s_at
11728231_at
16674998
205215_PM_at
205215_at
2371705
2371706
2371718
2371719
2371720
2371722
2371723
2371724
2371726
2371727
2371728
3198021
3198024
3198025
33484_at
60269_i_at
60270_r_at
6045
7908169
A_23_P85543
A_24_P199500
GE62501
GO:0000122
GO:0000151
GO:0000278
GO:0000791
GO:0000792
GO:0001702
GO:0001739
GO:0003682
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0007281
GO:0008270
GO:0009948
GO:0010467
GO:0016567
GO:0016604
GO:0016740
GO:0022414
GO:0030154
GO:0031519
GO:0035102
GO:0035518
GO:0036211
GO:0040029
GO:0043226
GO:0043433
GO:0046872
GO:0048856
GO:0061630
GO:0071339
GO:0071535
GO:0140096
GO:0140862
HMNXSV003001400
HMNXSV003017777
ILMN_1651715
PH_hs_0031611
TC01001595.hg
Y10571_at
g6005746_3p_at
Participates
as a component of
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
as a member of
RING1,RNF2 [nucleoplasm] (Homo sapiens)
Inferred To
RNF2 [nucleoplasm]
(Bos taurus)
RNF2 [nucleoplasm]
(Canis familiaris)
RNF2 [nucleoplasm]
(Gallus gallus)
RNF2 [nucleoplasm]
(Sus scrofa)
spat-3 [nucleoplasm]
(Caenorhabditis elegans)
rnf2 [nucleoplasm]
(Danio rerio)
rnf2 [nucleoplasm]
(Xenopus tropicalis)
Sce [nucleoplasm]
(Drosophila melanogaster)
Rnf2 [nucleoplasm]
(Mus musculus)
Rnf2 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
XP_011508154.1
,
XP_011508153.1
,
NP_009143.1
OpenTargets
ENSG00000121481
IntEnz
2.3.2.27
HPA
ENSG00000121481-RNF2
GeneCards
Q99496
Ensembl
ENSP00000356480
,
ENSP00000356479
,
ENSG00000121481
,
ENST00000367510
,
ENST00000367509
PRO
Q99496
Pharos - Targets
Q99496
HMDB Protein
HMDBP11563
PDB
7ND1
,
2H0D
,
4R8P
,
3RPG
,
8GRM
,
4S3O
,
3IXS
,
3GS2
,
6WI7
,
3H8H
,
6WI8
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.941
16
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.798
6
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.725
6
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.688
5
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.666
4
UniProt:P61077 UBE2D3
3
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
UBE2D3 [cytosol]
(R-HSA-934630)
UBE2D3 [nucleoplasm]
(R-HSA-205341)
0.666
6
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.643
4
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.527
3
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.527
3
UniProt:Q969R5 L3MBTL2
2
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
0.527
3
UniProt:P08183 ABCB1
1
ABCB1 [plasma membrane]
(R-HSA-1457534)
0.508
2
UniProt:Q9H7Z6 KAT8
1
KAT8 [nucleoplasm]
(R-HSA-3321802)
0.499
2
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