Reactome | BMI1 [nucleoplasm]

BMI1 [nucleoplasm]

Stable Identifier

R-HSA-389121

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Polycomb complex protein BMI-1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51, RNF51

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by E2F6 (Homo sapiens)
      - E2F6 binds the PRC1 complex (Homo sapiens)
        
        E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        BMI1,PCGF2 [nucleoplasm] (Homo sapiens)
        
        BMI1 [nucleoplasm] (Homo sapiens)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        BMI1,PCGF2 [nucleoplasm] (Homo sapiens)
        
        BMI1 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        BMI1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        BMI1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35226 BMI1

Gene Names

BMI1, PCGF4, RNF51

Chain

chain:1-326

Reference Genes

BioGPS Gene:100532731 BMI1

BioGPS Gene:648 BMI1

COSMIC (genes):BMI1 BMI1

CTD Gene:100532731 BMI1

CTD Gene:648 BMI1

dbSNP Gene:100532731 BMI1

dbSNP Gene:648 BMI1

ENSEMBL:ENSG00000168283 BMI1

HGNC:1066 BMI1

KEGG:hsa:100532731 BMI1

KEGG:hsa:648 BMI1

Monarch:100532731 BMI1

Monarch:648 BMI1

NCBI Gene:100532731 BMI1

NCBI Gene:648 BMI1

OMIM:164831 BMI1

UCSC:P35226 BMI1

Reference Transcript

Other Identifiers

11743395_s_at

11756843_a_at

1728_at

202265_PM_at

202265_at

2601877

3238492

3238493

3238494

3238495

3238496

3238497

3238498

3238499

3238500

3238501

3238502

3238503

3238504

3238505

3238506

3238507

3238508

3238509

3238510

3238511

3238512

3238513

3238514

3238515

3238516

41562_at

648

7926609

A_14_P135457

A_23_P314115

A_24_P303989

GE57630

GO:0000122

GO:0000151

GO:0000792

GO:0000978

GO:0001501

GO:0001701

GO:0002376

GO:0003677

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006346

GO:0006355

GO:0006959

GO:0007379

GO:0007420

GO:0008270

GO:0010468

GO:0016604

GO:0021903

GO:0030097

GO:0030890

GO:0031519

GO:0033092

GO:0035102

GO:0043226

GO:0043565

GO:0045814

GO:0046872

GO:0048103

GO:0048146

GO:0048704

GO:0048706

GO:0048856

GO:0051443

GO:0071535

GO:0097027

GO:0097190

GO:0098772

GO:1990841

GO:2000011

GO:2001234

HMNXSV003033732

ILMN_1700915

L13689_at

PH_hs_0018497

TC10002935.hg

g4885094_3p_at

g4885094_3p_x_at

Participates

as a component of

as a member of

BMI1,PCGF2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S-BMI1 [nucleoplasm]

monoSUMO1-K88-BMI1 [nucleoplasm]

Inferred To

bmi1 [nucleoplasm] (Xenopus tropicalis)

bmi1a [nucleoplasm] (Danio rerio)

BMI1 [nucleoplasm] (Bos taurus)

BMI1 [nucleoplasm] (Canis familiaris)

BMI1 [nucleoplasm] (Gallus gallus)

BMI1 [nucleoplasm] (Rattus norvegicus)

BMI1 [nucleoplasm] (Sus scrofa)

Psc [nucleoplasm] (Drosophila melanogaster)

Bmi1 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_001190991.1, NP_005171.4

OpenTargets

ENSG00000168283

ENSEMBL

ENSP00000365851, ENST00000376663

HPA

ENSG00000168283-BMI1

PRO

P35226

Pharos - Targets

P35226

GlyGen

P35226

PDB

6WI8, 6WI7, 8GRM, 3RPG, 2NA1, 2H0D, 4R8P, 7ND1, 5FR6, 8PP7

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.69	4
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.646	7
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.61	7
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.589	2
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.527	7
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.527	2
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:P17096 HMGA1	2	HMGA1 [cytosol] (R-HSA-3004619) HMGA1 [nucleoplasm] (R-HSA-3004623)	0.527	2
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.499	8