Reactome | SMARCA2 [nucleoplasm]

SMARCA2 [nucleoplasm]

Stable Identifier

R-HSA-389256

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hBrm

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P51531 SMARCA2

Gene Names

SMARCA2, BAF190B, BRM, SNF2A, SNF2L2

Chain

chain:1-1590

Reference Genes

BioGPS Gene:6595 SMARCA2

COSMIC (genes):SMARCA2 SMARCA2

CTD Gene:6595 SMARCA2

dbSNP Gene:6595 SMARCA2

ENSEMBL:ENSG00000080503 SMARCA2

HGNC:11098 SMARCA2

KEGG:hsa:6595 SMARCA2

Monarch:6595 SMARCA2

NCBI Gene:6595 SMARCA2

OMIM:600014 SMARCA2

UCSC:P51531 SMARCA2

Reference Transcript

Participates

as an input of

Formation of neuronal progenitor BAF (npBAF) (Homo sapiens)

as a member of

SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)

Inferred To

Smarca2 [nucleoplasm] (Mus musculus)

Smarca2 [nucleoplasm] (Rattus norvegicus)

swsn-4 [nucleoplasm] (Caenorhabditis elegans)

snf21 [nucleoplasm] (Schizosaccharomyces pombe)

smarca2 [nucleoplasm] (Xenopus tropicalis)

STH1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of SMARCA2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SMARCA2 [nucleoplasm] (Dictyostelium discoideum)

Homologues of SMARCA2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of SMARCA2 [nucleoplasm] (Schizosaccharomyces pombe)

SNF2 [nucleoplasm] (Saccharomyces cerevisiae)

pqn-15 [nucleoplasm] (Caenorhabditis elegans)

snf22 [nucleoplasm] (Schizosaccharomyces pombe)

SMARCA2 [nucleoplasm] (Bos taurus)

SMARCA2 [nucleoplasm] (Canis familiaris)

SMARCA2 [nucleoplasm] (Dictyostelium discoideum)

SMARCA2 [nucleoplasm] (Gallus gallus)

SMARCA2 [nucleoplasm] (Plasmodium falciparum)

brm [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_003061.3, NP_001276325.1, NP_001276326.1, NP_620614.2

Guide to Pharmacology - Targets

2739

OpenTargets

ENSG00000080503

ENSEMBL

ENST00000382194, ENSP00000349788, ENST00000357248, ENST00000382203, ENSG00000080503, ENST00000349721, ENSP00000371629, ENSP00000371638, ENSP00000265773

ZINC - Substances

SMCA2_HUMAN

ZINC target

P51531

PRO

P51531

GlyGen

P51531

PDB

8QJT, 9E31, 9D11, 9E30, 9E1K, 9D12, 6EG3, 6EG2, 8G1P, 7S4E, 4QY4, 5DKH, 5DKC, 7Z78, 6HAY, 6HAZ, 7Z6L, 6HAX, 7Z76, 2DAT, 7Z77

HPA

ENSG00000080503-SMARCA2

GeneCards

SMARCA2

Pharos - Targets

P51531

Orphanet

SMARCA2

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.848	12
UniProt:O14497 ARID1A	1	ARID1A [nucleoplasm] (R-HSA-389259)	0.757	6
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.725	6
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.716	5
UniProt:Q8NFD5 ARID1B	1	ARID1B [nucleoplasm] (R-HSA-5225635)	0.688	4
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.643	5
UniProt:Q92785 DPF2	1	DPF2 [nucleoplasm] (R-HSA-9727509)	0.643	5
UniProt:P04326 TAT			0.602	8
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.592	2
UniProt:Q9UHA2 S18L2			0.569	5
UniProt:P14921 ETS1	2	p-T38-ETS1 [nucleoplasm] (R-HSA-3132720) ETS1 [nucleoplasm] (R-HSA-1629809)	0.536	2
UniProt:Q92784-1 DPF3			0.527	4
UniProt:Q92784-2 DPF3			0.527	5
UniProt:Q8WUZ0 BCL7C	1	BCL7C [nucleoplasm] (R-HSA-9727457)	0.527	4
UniProt:Q4VC05 BCL7A	1	BCL7A [nucleoplasm] (R-HSA-9727449)	0.527	3
UniProt:Q92782 DPF1	1	DPF1 [nucleoplasm] (R-HSA-8855001)	0.527	3
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.524	2
UniProt:P51608 MECP2			0.524	4
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.508	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2
UniProt:A4PIW0 A4PIW0			0.462	2