Reactome | Activation of Rac1 by pVav1

Activation of Rac1 by pVav1

Stable Identifier

R-HSA-389348

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Upon activation by PIP3 binding and phosphorylation by Fyn kinase, Vav1 acts as a guanine nucleotide exchange factor (GEF) for Rac. Vav1 specifically catalyzes the exchange of GDP for GTP on Rac, leading to its activation. This process is crucial for downstream signaling events that regulate cell movement, cytoskeletal rearrangements, and immune cell function (Crespo et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
8990121	Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE	Nature	1997
9438848	Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav White, MA, Falck, JR, Mosteller, RD, Xia, Y, Han, J, Shu, X, Das, B, Luby-Phelps, K, Krishna, UM, Broek, D	Science	1998