F2RL1(37-397) [plasma membrane]

Stable Identifier
R-HSA-389418
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Proteinase-activated receptor 2, RecName: Full=Proteinase-activated receptor 2; Short=PAR-2; AltName: Full=Thrombin receptor-like 1; AltName: Full=Coagulation factor II receptor-like 1; AltName: Full=G-protein coupled receptor 11; Flags: Precursor;
GN Name=F2RL1; Synonyms=GPR11, PAR2;
OS Homo sapiens, PAR2_HUMAN, F2RL1
Locations in the PathwayBrowser
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General
This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
External Reference Information
External Reference
UniProt:P55085 F2RL1
Gene Names
F2RL1, GPR11, PAR2
Chain
signal peptide:1-25, propeptide:26-36, chain:37-397, chain:38-397, chain:39-397
Reference Genes
BioGPS Gene:2150 F2RL1
COSMIC (genes):F2RL1 F2RL1
CTD Gene:2150 F2RL1
dbSNP Gene:2150 F2RL1
ENSEMBL:ENSG00000164251 F2RL1
HGNC:3538 F2RL1
KEGG:hsa:2150 F2RL1
Monarch:2150 F2RL1
NCBI Gene:2150 F2RL1
OMIM:600933 F2RL1
UCSC:P55085 F2RL1
Reference Transcript
Other Identifiers
11728827_at
11728828_at
16986417
206429_PM_at
206429_at
213506_PM_at
213506_at
2150
2816495
2816496
2816498
2816499
36344_at
36345_g_at
38247_at
8106403
A_14_P117888
A_23_P58835
A_33_P3232945
GE59346
GO:0001648
GO:0001965
GO:0002020
GO:0002286
GO:0002376
GO:0002690
GO:0002720
GO:0003013
GO:0003014
GO:0003104
GO:0004930
GO:0005102
GO:0005515
GO:0005768
GO:0005769
GO:0005794
GO:0005886
GO:0006355
GO:0006954
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0007596
GO:0010804
GO:0015057
GO:0016020
GO:0030154
GO:0030193
GO:0030335
GO:0030836
GO:0031143
GO:0031274
GO:0031410
GO:0031681
GO:0032682
GO:0032722
GO:0032729
GO:0032731
GO:0032733
GO:0032755
GO:0032757
GO:0032930
GO:0034137
GO:0034140
GO:0034141
GO:0034145
GO:0034330
GO:0035025
GO:0038023
GO:0042119
GO:0042311
GO:0043122
GO:0043123
GO:0043226
GO:0043311
GO:0043547
GO:0045087
GO:0045217
GO:0045944
GO:0046328
GO:0046329
GO:0046330
GO:0046676
GO:0048856
GO:0048870
GO:0050900
GO:0050921
GO:0050927
GO:0051607
GO:0051897
GO:0060089
GO:0060100
GO:0061028
GO:0070374
GO:0070493
GO:0070661
GO:0070963
GO:0097029
GO:0098542
GO:0099109
GO:1900135
GO:2000341
HMNXSV003022090
Hs.168102.0.S1_3p_at
ILMN_1673113
ILMN_2041190
PH_hs_0009290
TC05000372.hg
TC05002459.hg
U34038_at
g8051581_3p_at
p33885
Participates
as a member of
Inferred To
f2rl1.1 [plasma membrane] (Danio rerio)
f2rl1 [plasma membrane] (Xenopus tropicalis)
F2RL1 [plasma membrane] (Bos taurus)
F2RL1 [plasma membrane] (Canis familiaris)
F2RL1 [plasma membrane] (Gallus gallus)
F2RL1 [plasma membrane] (Sus scrofa)
gnrr-4 [plasma membrane] (Caenorhabditis elegans)
F2rl1 [plasma membrane] (Mus musculus)
F2rl1 [plasma membrane] (Rattus norvegicus)
Cross References
RefSeq
Guide to Pharmacology - Targets
348
ENSEMBL
OpenTargets
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Investigational
HPA
Pharos - Targets
ZINC - Predictions - Purchasable
Interactors (5)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q15363 TMED2  5 0.704 6
 UniProt:P29066  6 0.599 6
 UniProt:P22681 CBL  20 0.556 3
 UniProt:P04156 PRNP  2 0.553 3
 UniProt:Q9BVG9 PTDSS2  1 0.547 2
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