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NPFFR1 [plasma membrane]
Stable Identifier
R-HSA-389429
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RecName: Full=Neuropeptide FF receptor 1; AltName: Full=G-protein coupled receptor 147; AltName: Full=RFamide-related peptide receptor OT7T022;
GN Name=NPFFR1; Synonyms=GPR147, NPFF1;
OS Homo sapiens, NPFF1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
Two NPFF receptors can bind neuropeptide FF (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR1 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZQ6 NPFFR1
Gene Names
NPFFR1, GPR147, NPFF1
Chain
chain:1-430
Reference Genes
BioGPS Gene:64106 NPFFR1
COSMIC (genes):NPFFR1 NPFFR1
CTD Gene:64106 NPFFR1
dbSNP Gene:64106 NPFFR1
ENSEMBL:ENSG00000148734 NPFFR1
ENSEMBL_homo_sapiens_GENE:ENSG00000148734.8 NPFFR1
HGNC:17425 NPFFR1
KEGG Gene (Homo sapiens):64106 NPFFR1
Monarch:64106 NPFFR1
NCBI Gene:64106 NPFFR1
OMIM:607448 NPFFR1
UCSC:Q9GZQ6 NPFFR1
Reference Transcript
RefSeq:NM_022146.4 NPFFR1
Other Identifiers
11732380_at
16715151
221387_PM_at
221387_at
3293309
3293311
3293313
3293314
3293315
3293316
3293317
3293318
3293320
3293323
3293324
3293331
3293332
3965441
59662_at
64106
7934141
A_23_P1452
GO:0004930
GO:0005515
GO:0005886
GO:0005929
GO:0007165
GO:0007186
GO:0007218
GO:0008150
GO:0008188
GO:0016020
GO:0023052
GO:0032870
GO:0042277
GO:0043226
GO:0060089
HMNXSV003054546
ILMN_1783336
PH_hs_0032577
TC10001363.hg
g11545886_3p_at
Participates
as a member of
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
Inferred To
NPFF1 [plasma membrane]
(Gallus gallus)
npffr1.1 [plasma membrane]
(Xenopus tropicalis)
SIFaR [plasma membrane]
(Drosophila melanogaster)
NPFFR1 [plasma membrane]
(Bos taurus)
NPFFR1 [plasma membrane]
(Canis familiaris)
NPFFR1 [plasma membrane]
(Sus scrofa)
Npffr1 [plasma membrane]
(Mus musculus)
Npffr1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_071429.1
Guide to Pharmacology - Targets
300
OpenTargets
ENSG00000148734
HPA
ENSG00000148734-NPFFR1
GeneCards
Q9GZQ6
ZINC - Substances
NPFF1_HUMAN
ZINC target
Q9GZQ6
Ensembl
ENST00000277942
,
ENSP00000277942
,
ENSG00000148734
PRO
Q9GZQ6
Pharos - Targets
Q9GZQ6
ZINC - Predictions - Purchasable
NPFF1_HUMAN
HMDB Protein
HMDBP07847
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.556
3
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