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HCRT(70-97) [extracellular region]
Stable Identifier
R-HSA-389473
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Orexin B, RecName: Full=Orexin; AltName: Full=Hypocretin; Short=Hcrt; Contains: RecName: Full=Orexin-A; AltName: Full=Hypocretin-1; Short=Hcrt1; Contains: RecName: Full=Orexin-B; AltName: Full=Hypocretin-2; Short=Hcrt2; Flags: Precursor;
GN Name=HCRT; Synonyms=OX, PPORX, PPOX;
OS Homo sapiens, OREX_HUMAN, HCRT
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRT(70-97) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRT(70-97) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRT(70-97) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRT(70-97) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRT(70-97) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
HCRT(70-97) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
Orexin 2 receptor can bind orexin-B neuropeptide (Homo sapiens)
HCRT(70-97) [extracellular region] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRT(70-97) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43612 HCRT
Gene Names
HCRT, OX, PPORX, PPOX
Chain
signal peptide:1-33, peptide:34-66, peptide:70-97, propeptide:98-131
Reference Genes
BioGPS Gene:3060 HCRT
COSMIC (genes):HCRT HCRT
CTD Gene:3060 HCRT
dbSNP Gene:3060 HCRT
ENSEMBL:ENSG00000161610 HCRT
ENSEMBL_homo_sapiens_GENE:ENSG00000161610.1 HCRT
HGNC:4847 HCRT
KEGG Gene (Homo sapiens):3060 HCRT
Monarch:3060 HCRT
NCBI Gene:3060 HCRT
OMIM:602358 HCRT
UCSC:O43612 HCRT
Reference Transcript
RefSeq:NM_001524.1 HCRT
Other Identifiers
11734517_at
16845073
207642_PM_at
207642_at
3060
31417_at
3757738
3757739
3757740
3757741
3757742
8015572
A_23_P129989
A_33_P3306624
GE588644
GO:0001659
GO:0005184
GO:0005576
GO:0005783
GO:0005791
GO:0006260
GO:0007200
GO:0007204
GO:0007205
GO:0007218
GO:0007268
GO:0007631
GO:0008021
GO:0008156
GO:0023052
GO:0030141
GO:0030431
GO:0031410
GO:0031771
GO:0031772
GO:0042594
GO:0042755
GO:0043226
GO:0043267
GO:0045202
GO:0046928
GO:0048018
GO:0048471
GO:0050877
GO:0051928
GO:0051970
GO:0051971
GO:0060079
GO:0098772
GO:0098794
GO:0120162
HMNXSV003037129
ILMN_2179739
PH_hs_0027899
TC17001527.hg
g4557634_3p_at
Participates
as an input of
Orexin 2 receptor can bind orexin-B neuropeptide (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
Other forms of this molecule
HCRT(34-66) [extracellular region]
Inferred To
hcrt [extracellular region]
(Danio rerio)
hcrt [extracellular region]
(Xenopus tropicalis)
HCRT(70-97) [extracellular region]
(Bos taurus)
HCRT [extracellular region]
(Canis familiaris)
HCRT [extracellular region]
(Gallus gallus)
HCRT [extracellular region]
(Sus scrofa)
Hcrt [extracellular region]
(Mus musculus)
Hcrt [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001515.1
OpenTargets
ENSG00000161610
HPA
ENSG00000161610-HCRT
GeneCards
O43612
Ensembl
ENSP00000293330
,
ENSG00000161610
,
ENST00000293330
PRO
O43612
Pharos - Targets
O43612
Orphanet
16189
HMDB Protein
HMDBP02340
PDB
1WSO
,
7L1U
,
1CQ0
,
1R02
,
1UVQ
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01909 HLA-DQA1
9
HLA class II histocompatibility antigen, DQ [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130716)
HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane]
(R-HSA-2130699)
HLA class II histocompatibility antigen, DQ [Golgi membrane]
(R-HSA-2214382)
HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane]
(R-HSA-2130568)
HLA class II histocompatibility antigen, DQ [transport vesicle membrane]
(R-HSA-2130733)
HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130595)
HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane]
(R-HSA-2130529)
HLA class II histocompatibility antigen, DQ [lysosomal membrane]
(R-HSA-2130686)
HLA class II histocompatibility antigen, DQ [plasma membrane]
(R-HSA-197585)
0.564
2
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